Medical & Biotech – Page 40 – TechConnect Briefs

Study of protoporphyrin IX-loaded silica hollow spheres for Photodynamic therapy

Tseng G-H, Liu T.Y., National Yang-Ming University of Taiwan, TW

In this study, PpIX was loaded in the shell of silica hollow sphere with the expectation that PpIX-loaded silica hollow spheres (PpIX-SHS) might be employed as a PDT agent with ultrasound image contrast. The PpIX-loaded [...]

Study on the polymeric nanosphere with imaging functionality

Lin M-H, Liu T.Y., Institute of Biomedical Engineering, National Yang-Ming University, Taipei, 112 Taiwan (ROC), TW

The aim of this research was to develop a novel contrast agent with magnetic resonance (MR) imaging, fluorescent imaging and drug encapsulation functionalities. The zinc oxide (ZnO) nanoparticles and superparamagnetic iron oxide (Fe3O4) nanoparticleswas prepared [...]

Novel Photo-thermal Controlled Drug-releasing Vectors for Cancer Detection and Treatment

Tsai M-H, Ling D., Shieh M.J., National Taiwan University, TW

Cancer is always the leading cause of deaths in worldwide. The aim of this research is to develop a new generation of chemotherapeutic drugs with both photothermal activated drug release and MRI diagnostic function. Carbon [...]

NanoBandage for Controlled Release of Topical Therapeutics

Patchan M., Calderon-Colon X., Benkoski J., Theodore M., Le H., Fuller B., Boggs N., Nelson A., Garza L., Sarkar K., Brandacher G., Patrone J., The Johns Hopkins University Applied Physics Laboratory, US

Burn injuries, trauma, and surgical procedures result in complex wounds, which can lead to pain, infection, and scarring. Management of complex wounds remains a critical challenge for the medical community and effective, localized treatments are [...]

Magnetic Field-Induced Cyclizations of Amino-Esters and -Carbonates Bound to Iron Oxide Nanoparticles

Knipp R.J., Uradu O., Nantz M.H., University of Louisville, US

We studied a panel of thermally sensitive amino-esters and amino-carbonates to evaluate their cyclization rates on heating. After analyzing the influence of chain length, steric factors, gem-dimethylation and additional functionalities, we have determined which ester [...]

Exploiting the “protein corona effect” for targeted drug and gene delivery

Caracciolo G., Pozzi D., Capriotti A.L., Cavaliere C., Cardarelli F., Salomone F., Laganà A., Sapienza University of Rome, IT

When administered in vivo lipid nanoparticles (NPs) are immediately covered by a rich protein layer, known as “protein corona” that changes the size, aggregation state, and interfacial properties of the NP, giving it a biological [...]

Peptide-Mediated Cellular Delivery of Semiconductor Quantum Dots

Gemmill K., Delehanty J., Stewart M., Susumu K., Oh E., Deschamps J., Blanco-Canosa J., Dawson P., Huston A., Medintz I., US Naval Research Laboratory, US

Semiconductor CdSe/Zn quantum dots are ideal materials for biological imaging due to their superior optical properties over fluorescent proteins and organic dyes. However, cytosolic cellular delivery of quantum dots has been hindered by endosomal sequestration [...]

Materials for Drug & Gene Delivery

Establishment of a Matrix for Biorecognition Reactions based on Responsive Polymeric Compounds

Fandrich A., Buller J., Wischerhoff E., Laschewsky A., Lisdat F., Technical University of Applied Sciences Wildau, DE

Thermo-responsive polymers were synthesized and covalently bound to the surface of gold electrodes. Subsequently cyclic voltammetric and impedimetric measurements with so prepared working electrodes were realised in aqueous potassium ferro-/ferricyanide solutions at different temperatures. Significant [...]

Carbon nanotubes-metal nanoparticle heterostructures embedded within stimuli-responsive hydrogel for controlled delivery applications

Shi W., Venkatanarayanan A., Chopra N., The University of Alabama, US

In this work we report a novel hybrid hydrogel by embedded complex carbon nanotube-metal nanoparticle architectures within a hydrogel network. This leads to a novel triggering mechanism for release of multiple chemical species at controlled [...]