Medical & Biotech – Page 24 – TechConnect Briefs

Targeted delivery of anti-cancer drug sorafenib through magnetic solid lipid nanoparticles

Grillone A., Redolfi Riva E., Moscato S., Sacco R., Mattoli V., Ciofani G., Italian Institute of Technology, IT

The multi-kinase inhibitor sorafenib (tradename Nexavar®, Bayer) has been recently approved by the FDA for the treatment of non-resectable hepatocarcinoma and advanced renal carcinoma. Despite its proven survival benefit, sorafenib can lead to important side [...]

Dielectrophoretic Isolation and Detection of Cancer Related DNA and RNA Nanoparticulate Biomarkers from Blood and Plasma

Heller M.J., Marciniak J., Skowronski E., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA and RNA nanoparticulate biomarkers continues to become more widely used for cancer diagnostics and management. Generally, cfc-DNA for “liquid biopsies” is isolated form plasma using relatively long [...]

Cancer Nanotechnology

A New and versatile method for preparing crystalline drug nanoparticle formulations

Higgins J.D., Merck Research Labs, US

The birth of the nanoparticle (nanos) drug delivery field arguably was seen over 20 years ago with the advent and application of simple oral crystalline nanoparticle formulations. This effective approach for enhancind oral absorption using [...]

Co-Culturing Dorsal Root Ganglion Neurons with Schwann Cells Protects Them Against the Cytotoxic Effects of Silver Nanoparticles

Gao W., Leung S.W., Bhushan A., Lai J.C.K., Idaho State University College of Pharmacy, US

Because of their presumed inertness, silver nanoparticles are increasing employed in many consumer products. Nonetheless, their environmental and health hazard impact are not understood. Our previous studies led us to develop a co-culture model consisting [...]

Schwann Cells and Dorsal Root Ganglion Neurons Are Differentially Susceptible to Oxidative Stress Induced by Silicon Dioxide Nanoparticles

Lai J.C.K., Jaiswal A.R., Idikuda V.K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Silicon dioxide (SiO2) particles, including nanoparticles, have been increasing employed in diverse industrial and biomedical applications including those in drug formulations, food, and cosmetics as SiO2 has been generally regarded as a non-toxic substance. However, [...]

PLGA and PLGA-PEG nanoparticles loaded with curcumin and their effect on aflatoxin B1 in vitro

Rivero-Gonzalez A., Ramirez-Noguera P., Universidad Nacional Autonoma de Mexico, MX

The aim of this study was to evaluate the effect of nanoparticles prepared with polylactic-co-glycolic acid (PLGA) and PLGA with polyethylene glycol (PLGA-PEG) loaded with curcumin in human hepatocytes exposed to aflatoxin B1 in vitro. [...]

Peptide RF482 Encapsulated Chitosan – PLGA Nanoparticles Inhibit Respiratory Syncytial Virus

Bawage S.S., Tiwari P.M., Dennis V.A., Singh S.R., Alabama State University, US

Worldwide, human respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infections in children and older adults. Currently, an anti-viral drug ribavirin and RSV neutralizing monoclonal antibody- palivizumab are the [...]

The use of Werner complexes as remarkably versatile bioconjugation reagents in the synthesis of redox repsonsive albumin nanoparticles containing camptothecin derivatives

Cavazos R.J., Morrison C.S., Lampe J.B., Nguyen D.T., Harris A.N., McFarlin B.K., Petros R.A., University of North Texas, US

Alfred Werner, the father of inorganic chemistry, received the Nobel Prize in 1913 for his pioneering work in formulating a theory to describe bonding patterns for coordination compounds. A number of complexes studied were amine [...]

Efficiency of different chitosan and its derivative nanoparticles for delivery of recombinant plasmid of Tibetan pig interleukin-7 gene and regulation effect in vivo on immune responses of mice

Wan X.P., Wang Z.Z., Yang X., Lang G., Sun W.K., Chen Y-H, Li J.L., Liu R., Gu Y.R., Liu R., Wang Z.Z., Lu X.B., Gao R., Sichuan University, CN

For sake of developing safe and effective technique to deliver and express animal immune gene in vivo to enhance comprehensive immunity of animal against infectious disease, the interleukin-7 gene of Tibetan pig was firstly cloned [...]