Medical & Biotech – Page 155 – TechConnect Briefs

Electrostatic Droplet Ejector with Monolithic Fabrication of Nozzle

Lee S-H., Byun D.Y., Ko H.S., Kim Y., Yang J.H., Han S.J., Son S.U., Oh J.T., Konkuk University, KR

This paper presents a novel mechanism of electrostatic micro droplet formation and ejection of fluid. Unlike conventional electrostatic jetting which requires a high operating voltage, we offer a, commercially viable, low operating voltage for droplet-on-demand [...]

Dimensioning of a New Micro-Needle for the Dispense of Drugs in Tumors and Cell Clusters

Berthier J., Rivera F., Caillat P., Berger F., CEA-LETI, FR

In medical treatment, there is a constant need to deliver active molecules into targeted cells, but this dispense is often difficult and time consuming. For example, in cancerology, it has been shown that active molecules [...]

A Computational Model for the Design of ElectroWetting On Dielectric (EWOD) Systems

Bedekar A.S., Jenkins J.W., Sundaram S., CFD Research Corporation, US

Microfluidics has enabled the development of integrated lab-on-a-chip (LoC) devices for use in a clinical diagnostics, high throughput screening, drug discovery, biodefense and environmental monitoring. Although most microfluidic devices are based on continuous flow of [...]

Inkjet Assisted Micro-Scale Cooling of Electronics

Sharma R.K., Bash C.E., Patel C.D., Hewlett Packard Co. Laboratories, US

Rise in the overall power dissipation of computer systems has posed a severe challenge for cooling microprocessors. Increases in microprocessor power dissipation and the resulting effect on the cost and complexity of thermal management solutions [...]

Microfluidics and Lab on Chip

Bioinspired Miniaturization – Stretching Information from Coherence to Dissipation for Nano-to-Micro Integrated Intelligent Systems

Santoli S., International Nanobiological Testbed Ltd., IT

From previous results attained on the basis of thermodynamics, statistical physics and nanobiology it is shown that Artificial Intelligence (AI) concepts and their hard-wired implementations cannot satisfy the physical conditions for mimicking biological intelligence and [...]

Johnson-Kendall-Roberts Theory Applied to Living Cells

Chu Y-S, Dufour S., Thiery J.-P., Perez E., Pincet F., Laboratoire de Physique Statistique de l'ENS, FR

Cell adhesion is involved in a number of biological processes ranging from transport to the defenses of organisms. A quantitative understanding of the adhesion of cells is not often possible owing to their complexity in [...]

Ion Channel Simulations by the TR-PNP Model and the Excess Chemical Potential Approach

Hu S., Hess K., Beckman Institute, University of Illinois at Urbana-Champaign, US

We describe a new method referred to as TR-PNP model to study general types of nanostructure ion channels. Our method extends the common continuum methods to include particle like properties, such as the ion trapping [...]

Systems Biology Conceptual Modeling by Means of Discrete-event Simulation (DNA-RNA-Protein)

Yeol J.W., Barjis I., Barjis J., Barjis I., Barjis J., Berri S., Ryu Y., Polytechnic University, US

In this paper discrete-event simulation modeling technique is used to model and simulate biological processes. In particular, we study application of discrete-event simulation to model processes taking place in Glycolosis and capture dynamic behavior of [...]

A Multi-scale, Integrative Model of Cellular Electrophysiological Response Incorporating Intra/Extra-cellular Transport & Dynamics

Feng J.J., Krishnamoorthy S., Sundaram S., CFD Research Corporation, US

Spurred by the growing confluence of nano and bio technologies, several novel micro/nano platforms (see for example, whole cell patch clamp devices [1]) are emerging for the high-throughput and/or high-fidelity study of the electrophysiological response [...]