Advanced Materials & Manufacturing – Page 88

Inhalable Stimuli-Responsive Theranostic Nanoparticles for Cancer in Deep Lung Tissue

Abbas Y.H., American University in Cairo, EG

Lung cancer is the deadliest solid tumour among all types of cancer. Despite advances in surgery and drug discovery lung cancer remains difficult to treat. This is a result of unavoidable exposure to carcinogens, poor [...]

Characterisation of THP-1 macrophages as an in vitro model for CD44-targeted therapies

M. Rios de la Rosa J., Tirella A., Gennari A., Tirelli N., University of Manchester, UK

CD44 is the major cell surface receptor of hyaluronic acid (HA) and mediates the response of cells to their cellular microenvironment. Whereas the standard isoform (CD44s) is ubiquitously expressed throughout the body, variant isoforms (CD44v) [...]

Oxidized Graphene Nanoribbons as a Delivery System for the Bioactive Sphingolipid Ceramide

Suhrland C., Truman J.P., Sitharaman B., Stony Brook University, US

Dysregulation of the metabolic pathways of the sphingolipid ceramide has been shown to play key roles in cancer cell proliferation and survival. Targeting these pathways with exogenous modulators of ceramide metabolism such as the short [...]

Uptake Behavior of Glycoconjugated and Micellar-Encapsulated Quantum Dots on HeLa Cervical Cancer Cells

Merkl J.-P., Schmidtke C., Safi M., Muroski M., Alpers D., Tran H., Ostermann J., Kreuziger A.-M., Strouse G., Mattoussi H., Weller H., University of Hamburg, DE

Glyconanomaterials are of great interest for bio-imaging to understand biological processes, for instance metabolism, cell-cell or virus-cell interactions, gluconeogenesis, and cancer. Herein, we present a strategy for the biofunctionalization of fluorescent quantum dots (QDs) from [...]

Targeted delivery of anti-cancer drug sorafenib through magnetic solid lipid nanoparticles

Grillone A., Redolfi Riva E., Moscato S., Sacco R., Mattoli V., Ciofani G., Italian Institute of Technology, IT

The multi-kinase inhibitor sorafenib (tradename Nexavar®, Bayer) has been recently approved by the FDA for the treatment of non-resectable hepatocarcinoma and advanced renal carcinoma. Despite its proven survival benefit, sorafenib can lead to important side [...]

Dielectrophoretic Isolation and Detection of Cancer Related DNA and RNA Nanoparticulate Biomarkers from Blood and Plasma

Heller M.J., Marciniak J., Skowronski E., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA and RNA nanoparticulate biomarkers continues to become more widely used for cancer diagnostics and management. Generally, cfc-DNA for “liquid biopsies” is isolated form plasma using relatively long [...]

Cancer Nanotechnology

A New and versatile method for preparing crystalline drug nanoparticle formulations

Higgins J.D., Merck Research Labs, US

The birth of the nanoparticle (nanos) drug delivery field arguably was seen over 20 years ago with the advent and application of simple oral crystalline nanoparticle formulations. This effective approach for enhancind oral absorption using [...]

Co-Culturing Dorsal Root Ganglion Neurons with Schwann Cells Protects Them Against the Cytotoxic Effects of Silver Nanoparticles

Gao W., Leung S.W., Bhushan A., Lai J.C.K., Idaho State University College of Pharmacy, US

Because of their presumed inertness, silver nanoparticles are increasing employed in many consumer products. Nonetheless, their environmental and health hazard impact are not understood. Our previous studies led us to develop a co-culture model consisting [...]

Schwann Cells and Dorsal Root Ganglion Neurons Are Differentially Susceptible to Oxidative Stress Induced by Silicon Dioxide Nanoparticles

Lai J.C.K., Jaiswal A.R., Idikuda V.K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Silicon dioxide (SiO2) particles, including nanoparticles, have been increasing employed in diverse industrial and biomedical applications including those in drug formulations, food, and cosmetics as SiO2 has been generally regarded as a non-toxic substance. However, [...]