Advanced Materials & Manufacturing – Page 164

Lysozyme – alginate nanocomplex: Effect of alginate composition

Fuenzalida J.P., Nareddy P.K., Moreno-Villoslada I., Moerschbacher B., Swamy M.J., Goycoolea F.M.A., Westfälische Wilhelms-Universität Münster, DE

In the present work we investigated the electrostatic self-assembly of nanoparticles of Lyz and different alginates (Alg A Mw~4kD and M/G~1.42 or Alg B Mw~7kD and M/G~5.00)to establish a relationship between the alginate structure and [...]

Epidermal Growth Factor-Ferritin H-Chain Nanoparticles as Nanocarrier of

Huang Y., Chen X., Cao X., East China University of Science and Technology, CN

The emergence of drug-resistant cancer cells together with the toxicity side effect of chemotherapy agents are the major obstacle in cancer treatment. We focused on providing a new pattern of protein-based nanoparticle as drug delivery [...]

Cationic lipid nanoemulsions for RNAi screening

Bruniaux J., Sulpice E., Mittler F., Texier I., Gidrol X., Navarro F.P., CEA/LETI/MINATEC, FR

Since the discovery of RNA interference, many efforts have been made to broaden perspectives of small interfering RNA (siRNA) in research and clinical work. siRNA shows a specific and effective gene silencing activity through a [...]

Commercializing unique nanoparticle-imaging-delivery platform technology for enhanced cancer therapy

Fu A., NVIGEN, Inc., US

In this presentation, we will talk about a unique nanoparticle-imaging-delivery platform developed at NVIGEN, Inc. for enhanced cancer therapeutic applications. Our proprietary nanoparticle-imaging-delivery (NID™) technology is a hybrid platform comprised of an intrinsically signal-generating component [...]

Fabrication of stable bio-compatible mesoporous silica and core-shell silica-magnetite nanoparticles for potential application in drug delivery

Sharifabad M.E., Mercer T., Sen T., University of Central Lancashire, UK

Superparamagnetic iron oxide nanoparticles (SPIONs) have become increasingly attractive materials in the field of Nano / Nano-biotechnology due to their potential applications in heteogeneious catalysis [1, 2], nanomedicine such as drug delivery [3, 4], cell [...]

Development of Drug Delivery System Using Bio based Calcium carbonate Nanoparticles

Render D., Rangari V., Samuel T., Ramapuram J., Pawar K., Jeelani S., Tuskegee University, US

The CaCO3 nanoparticles were derived from egg shells using sonochemical and mechanochemical methods. The glycerol and acetic acid were used as solvents in this process to avoid other toxic solvents. These nanoparticles were loaded with [...]

Non-ionic Dendronized Multiamphiphilic Polymers as Nanocarriers for Biomedical Applications

Gupta S., Schade B., Kumar S., Böttcher C., Haag R., Sharma S.K., University of Delhi, IN

Several supramolecular architectures on the nanoscale have become important candidates for potential applications in nanomedicine, particularly for drug, dye, and gene delivery. Out of various conceptual extensions for the development of such molecular objects, our [...]

Programming and switching the pharmacokinetics of nanoscale delivery vehicles in vivo

Chien M.-P., Gianneschi N.C., University of California San Diego, US

It has been shown that the morphology of nanomaterials greatly impacts the pharmacokinetic profile of the material, with larger micronscale fibril-like objects having longer circulation times while smaller nanomaterials show a greater rate of internalization [...]

Nanosystem for targeting Treg in vivo

Bottini M., Bottini N., Sacchetti C., Rapini N., Rosato N., Magrini A., Bottini M., Bottini N., Sanford Burnham Medical Research Institute, US

Due to their ability to suppress the activity of autoreactive cells, “natural” CD4+ CD25high FoxP3+ T cells (Treg) are important drug targets for autoimmune diseases and malignancies. Immunological studies are revealing a growing subset of [...]

Lipid nanoparticles for enhancing immune responses to protein antigens

Courant T., Reynaud H.L., Hoang A., Villiers C., Mittler F., Texier I., Marche P.N., Navarro F.P., CEA/LETI/MINATEC, FR

In the near future, novel vaccines will be needed, particularly nanoparticles-based vaccine formulations for figthing problematic infectious diseases like tuberculosis, AIDS/ HIV or malaria and also cancers. Here, we described the development of versatile chemical [...]