Advanced Materials & Manufacturing – Page 165

Thermosensitive Vaginal Gel Containing PLGA-NTRI Conjugate Nanoparticles for HIV Prophylaxis

Rajca A., Li Q., Date A., Destache C., Creighton University School of Pharmacy & Health Professions, US

A critical component to the prevention of the sexual transmission of HIV is adherence to the prevention modality. We have conjugated nucleoside-reverse transcriptase inhibitors (NRTIs) to a biocompatible polymer, PLGA using an amide bond. We [...]

Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular deliery of doxorubicin

Saravanakumar G., Shin J.M., Um W., Park J.H., Sungkyunkwan University, KR

Disulfide-containing HA dodecyl conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction as the carrier for intracellular delivery of doxorubicin (DOX). Owing to its amphiphilicity, HA-SS-DDT could form self-assembled nanoparticles in an aqueous condition. The [...]

Approaches to surface-functionalised materials for biomedical applications

Pitt D.W., Treharne A., Grossel M.C., University of Southampton, UK

There are many types of retinal disease which vary widely, with some being easier to treat than others. One such example is Age-Related Macular Degeneration (AMD) which is the largest cause of blindness for those [...]

A Molecular Modeling Approach towards Engineering of Polymer Nanogels for Controlled Drug Delivery

Dutta R.C., Rai B., Tata Research Development and Design Centre, IN

Traditionally, a drug is administered initially at a higher dosage so as to repeat the next dose after several hours or days. This, besides being un-economical, results in side effects. Recently, there has been an [...]

Reverse Thermoresponsive Polymers for Sustained Delivery of Therapeutic Agents

Mayadunne R., Balachandra A., Gunatillake T., Lindall C., CSIRO, AU

CSIRO has developed thermoresponsive polymers for encapsulation and sustianed release of bioactives. They are stable aqueous solutions over 24 months, easily pass through a 25 gauge needle at room temperature and immediately gel into a [...]

Effect of cholesterol on the transfection efficiency of DOTAP-containing lipoplexes

Pozzi D., Cardarelli F., Salomone F., Marchini C., Amenitsch H., Caracciolo G., Sapienza University of Rome, IT

Here, we have studied the effect of cholesterol on the transfection efficiency (TE) of cationic liposomes made of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and dioleoylphosphocholine (DOPC) in Chinese hamster ovary (CHO) cells. We held the charge of the [...]

Gold-Coated Liposomes Encapsulating Signaling Molecules for Initiating Cellular Communication

Orsinger G.V., Romanowski M., University of Arizona, US

To better understand the complex communication pathways of the tumor microenvironment, and therefore better design and develop therapies and diagnostics for cancers, experimental methods of probing cellular communication at a single to multi-cell level are [...]

Study of protoporphyrin IX-loaded silica hollow spheres for Photodynamic therapy

Tseng G-H, Liu T.Y., National Yang-Ming University of Taiwan, TW

In this study, PpIX was loaded in the shell of silica hollow sphere with the expectation that PpIX-loaded silica hollow spheres (PpIX-SHS) might be employed as a PDT agent with ultrasound image contrast. The PpIX-loaded [...]

Study on the polymeric nanosphere with imaging functionality

Lin M-H, Liu T.Y., Institute of Biomedical Engineering, National Yang-Ming University, Taipei, 112 Taiwan (ROC), TW

The aim of this research was to develop a novel contrast agent with magnetic resonance (MR) imaging, fluorescent imaging and drug encapsulation functionalities. The zinc oxide (ZnO) nanoparticles and superparamagnetic iron oxide (Fe3O4) nanoparticleswas prepared [...]

Novel Photo-thermal Controlled Drug-releasing Vectors for Cancer Detection and Treatment

Tsai M-H, Ling D., Shieh M.J., National Taiwan University, TW

Cancer is always the leading cause of deaths in worldwide. The aim of this research is to develop a new generation of chemotherapeutic drugs with both photothermal activated drug release and MRI diagnostic function. Carbon [...]