Papers – Page 783 – TechConnect Briefs

Detection of Small Molecule-Protein Binding with Amorphous Silicon Nanostructures

Lund J., Mehta R., Parviz B., University of Washington, US

We present the fabrication and characterization of a nano-scale sensor made of amorphous silicon (a-Si) for electronic detection of small molecule –protein binding. The main component of the detector is a nano-scale a-Si semicircle with [...]

Using Surface Plasmon Propagation through Nanostructures for Chemical and Biological Sensing

Benahmed A., Ho C-M., UCLA, US

By taking advantage of the properties of the propagation of surface plasmon waves through nanostructures, we developed a new chemical and biological sensor. Compared to traditional Surface Plasmon Resonance (SPR) sensing, our sensor does not [...]

Integrated Techniques for Transmembrane Protein Sensing

Wilk S.J., Petrossian L., Goryll M., Thornton T.J., Goodnick S.M., Tang J.M., Eisenberg R.S., Arizona State University, US

We present a method for the microfabrication of apertures in a silicon substrate using well-known cleanroom technologies and a novel approach using phase sensitive detection to measure single channels of transmembrane proteins. These proteins are [...]

Multi-plex biomolecular detection using Bio-nanotransduction

Branen J.R., University of Idaho, US

Bio-nanotransduction is a biological detection scheme that is based on biological recognition (Bio) and the production of biological nano-signals which allows the change of recognition event into universal signal molecules (nanotransduction). A single sample can [...]

Detection of Biological Species by Surface Enhanced Raman Scattering

Sengupta A., Volny M., Wilson C.B., Turecek F., Davis E.J., University of Washington, US

The rationale behind this work is to explore the application of surface-enhanced Raman scattering (SERS) to detect and identify biological species, especially some common pathogens that are involved in food poisoning and water contamination. SERS [...]

Future of Semiconductor Based Thermal Neutron Detectors

Nikolic R.J., Cheung C-L, Reinhardt C.E., Wang T.F., Lawrence Livermore National Lab., US

Thermal neutron detectors have seen only incremental improvements over the last decades. In this paper we overview the current technology of choice for thermal neutron detection – 3He tubes, which suffer from, moderate to poor [...]

Dendrimer Nanoparticles for Extending Biosensor Lifetime

Qian X., Tabacco M.B., Smiths Detection, US

Smiths Detection has been developing semi-selective optical biosensors for the direct airborne detection of the four primary classes of biological warfare agent: bacteria, bacterial spores, toxins and viruses. The sensors have good sensitivity and selectivity. [...]

Increasing the Thermal Stability of Self-Assembling DNA Nanostructures by Incorporation of isoG/isoC Base Pairs

Ho K., Li H., Roesch E.B., Sherrill C.B., Prudent J.R., LaBean T.H., Duke University, US

Self-assembling DNA nanostructures are currently being developed for a variety of applications in nanofabrication and molecular computing. For many uses, these nanostructures would benefit from increased thermal stability. However, increasing the lengths of sticky-ends that [...]

Patterned nanofiber meshes for biomedical applications

Neves N.M., Campos R., Pedro A., Cunha J., Macedo F., Reis R.L., University of Minho, PT

The typical end-product of the electrospinning process is a randomly aligned fibre mesh or membrane. This is a result of the electric field generated between the drop of polymer solution at the needle and the [...]

In vitro testing of the penetration and permeation of nanomaterials on a artificial human skin model

Weimer M., Mertsching H., Brunner H., Fraunhofer Institute of Interfacial Engineering and Biotechnology, DE

We established a tissue engineered 3D human skin model. This interactive 3D-co-cultre consists of living human primary keratinocytes with a well-differentiated stratum corneum and an epidermal layer. The dermal layer is composed of a Type [...]