peptide – TechConnect Briefs

Computation-assisted nanopore detection of uranyl ions

Roozbahani G.M, Chen X., Zhang Y., Guan X., Illinois Institute of Technology, US

Because of uranium mining, nuclear power production, nuclear weapon development, as well as other industrial and medical application, uranium has been one of the most common radioactive contaminants in the environment, which raises concerns about [...]

Platform Reagent Development for the Intracellular Delivery of Therapeutic Peptides

Evans B.C., Lander C., Duvall C.L., Moerae Matrix, Inc., US

Peptides hold many advantages over the small molecule drugs that dominate the current healthcare market in terms of potency, specificity, and biocompatibility, and they are faster and easier to implement than genetic modifications for completion [...]

Enhanced bioavailability of peptide YY using nanoporous silicon as a drug carrier

Kovalainen M., Monkare J., Makila E., Salonen J., Lehto V-P, Herzig K-H, Järvinen K., University of Turku, FI

Biomedical applications of inorganic nanomaterials have been actively investigated during the last years. Porous silicon (PSi) is one of those new promising materials possessing several attractive properties. It is biodegradable and considered to be safe [...]

Role of Serum Proteins in the Cellular Uptake of Gold-Peptide Nanoconjugates

Wang G., Papasani M.R., Hrdlicka P.J., Hill R.A., University of Idaho, US

Gold nanoparticles (Au NPs) have been widely investigated as promising nanocarriers for therapeutics and other biologically active molecules. In the present study, two different cysteine-terminated peptides were used to form nanoconjugates with Au NPs (20 [...]

Organisation of peptide ligands on the surface of gene vectors

Wang M., Miller A.D., Thanou M., Imperial College London, UK

Through the considerate organisation of surface ligands, we have developed a lipid-based vector for the targeted delivery to cancer cells. Our ligand is a short peptide with high affinity for the Urokinase Plasminogen Activator receptor [...]

A Sensitive Peptide-Nanotube Based Pathogen Assay

MacCuspie R.I., Banerjee I.A., Gummalla S., Mostowski H., Krause P., Matsui H., Hunter College, US

A novel peptide nanotube-based multiplexed pathogen assay has been developed that has high sensitivity, detecting as few as 100 pathogens per mL in as little as 0.5mL. Multifunctional nanotubes detect viruses by selectively binding antibody [...]