nanotoxicity – TechConnect Briefs

Enhancement of Effects of Chitosan and Nanoparticles on Pancreatic Cancer Cells by Combination Treatments with the Anti-Cancer Drug Adriamycin

Lai J.C.K., Gao W., Bhushan A., Leung S., Idaho State University College of Pharmacy, US

Because of chitosan’s roles in biomedical applications, this study investigated the effects of chitosan, chitosan in combination with silver or gold nanoparticles, and chitosan with nanoparticles and Adriamycin, Methotrexate or Cisplatin on human PANC-1 pancreatic [...]

Cytotoxic Effects of Short Multi-Wall Carbon Nanotubes on Pancreatic Cancer Cells

Lai J.C.K., Desai V., Zhang Y., Bhushan A., Leung S., Idaho State University College of Pharmacy, US

Although carbon nanotubes (CNTs) are increasingly exploited in diverse industrial and biomedical applications, their health hazard to humans is poorly understood. We have developed many cell models in vitro to systematically study the putative cytotoxicity [...]

Fluorescent quantum dot as model imaging probe for studying plant uptake, systemic mobility, localization in plant tissue and potential fate of ultra-small nanoparticles

Das S., Tharkur J., Tetard L., Gesquiere A., Santra S., University of Central Florida, US

Semiconductor fluorescent quantum dots (Qdots) are popularly used as bioimaging taggants in live cell imaging and spectroscopy. In recent years, Qdots taggants are emerging in agricultural applications. Studies are primarily focused on nanotoxicity of ultra-small [...]

Unexpected interactions of nanoparticles with endothelial and epithelial cells

Leong D.T., National University of Singapore, SG

Nanoparticles regardless as subjects of nanotoxicity or nanomedicine studies will inevitably interact with endothelial and epithelial cells. In the case of nanomedicine, while these cells are usually not the intended target, nanoparticles first interact with [...]

NanoSAR: Linking the structure of engineered nanomaterials with their toxicity

Oksel C., Ma C.Y., Wang X.Z., University of Leeds, UK

As the production and use of engineered nanomaterials (ENMs) are increasing, we are approaching the point at which it is impossible to individually assess the toxicity of a vast number of ENMs. Considering the large [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Human Neuroblastoma and Astrocytoma Cells

Lai J.C.K., Lai M.B., Balaraju A.K., Neti A., Lai J.C.K., Lai M.B., Tadinada S.M., Idikuda V.K., Singh M.R.M., Mukka K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Because of their escalating uses in industrial and biomedical applications, humans are increasing exposed to nanoparticles in occupational and other environmental settings. However, the environmental safety and health impact of such particles have not been [...]

Development of In-Vivo Screening Benchmarks for Complex Engineered Nanomaterials

Mahoney S., Najera M., Bai Q., Burton E., Veser G., University of Pittsburgh, US

This works investigates embedding metal nanoparticles (NPs) in porous silica shells to reduce or entirely mitigate the metal NPs toxicity while still providing access to the metal NP surface; hence maintaining functionality of the embedded [...]

Entry of Short Multi-Wall Carbon Nanotubes into Dorsal Root Ganglion (DRG) Neurons Induces Cell Death

Lai J.C.K., Gao W., Bhushan A., Bearden S.E., McDougall L., Leung S.W., Idaho State University College of Pharmacy, US

Carbon nanotubes (CNTs) have found their way into diverse industrial and biomedical applications because of their unique physico-chemical properties. However, the human health impact of exposure to CNTs is unknown. Our recent and ongoing studies [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells

Tadinada S.M., Lai J.C.K., Lai M.B., Idikuda V.K., Mukka K., Singh M.R.M., Pfau J., Bhushan A., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy, US

Targeted drug delivery systems with minimal potential adverse/side effects are gaining utility in diverse applications. Uses of nanomaterials to design such targeted drug delivery are escalating exponentially. Nevertheless, the biocompatibility of nanomaterials is inadequately addressed. [...]

High Throughput Screening of Nanomaterials: The Arkansas Research Consortium in Nanotoxicity, a partnership between Arkansas and the FDA

Howard P.C., Biris A.S., Salamo G.J., Zharov V.P., Buchanan R.A., Arkansas Research Alliance, US

The state of Arkansas and the FDA Center of Toxicological Research have begun a collaborative effort to develop techniques for high-throughput, rapid screening of existing and yet-to-be developed nanomaterials. To accomplish this the Arkansas Research [...]