nanotoxicity – Page 2 – TechConnect Briefs

Direct observation of silver nanoparticle-ubiquitin corona formation

Ding F., Clemson University, US

The advancement of nanomedicine and the increasing applications of nanoparticles in consumer products have led to administered biological exposure and unintentional environmental accumulation of nanoparticles, causing concerns over the biocompatibility and sustainability of nanotechnology. Upon [...]

Differential Cytotoxic Effects of Titanium Oxide Nanoparticles on Peripheral Nervous System Neural Cells

Lu S., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University College of Pharmacy, US

The health impact of exposure to TiO2 nanoparticles is poorly documented although exposure to the particles is known to elicit inflammatory responses in lung tissue. We recently found treatment with TiO2 micro- or nanoparticles induce [...]

Cell Culture Media elicit a different dynamic Formation of Protein-NP Complexes: Effects on the Cellular Response

Sabella S., Maiorano G., Sorce B., Brunetti V., Malvindi M.A., Cingolani R., Pompa P.P., Italian Institute of Technology, IT

We show that the dynamics of proteins-NP interactions are differently mediated by different cellular media, which are the liquid environments where NPs encounter cells. We used, as a model, spherical NPs (citrate-capped gold nanoparticles, AuNPs) [...]

The Use of Nanoscale Zero Valent Iron for Environmental Remediation – Benefits and Possible Pitfalls

Chan-Remillard S., Borda M., Crawford A., Kloschinsky T., Stenroos P., Marques L., Goudey J.S., HydroQual Ltd and Golder Associates Ltd/Inc., CA

Nanoscale zero valent iron (nZVI) is the primary nanoscale particle that is being used for environmental remediation of contaminated groundwater and soils. Golder Associates Ltd. and HydroQual Laboratories (a wholly owned subsidiary of Golder) has [...]

Gold nanoparticles caused learning impairment in mice

Chen Y-S, Hung Y.-C., Liau I., Lin L.-W., Hong M.-Y., Huang G.S., National Chiao Tung University, TW

Aims : To investigate the toxic effect of gold nanoparticles (GNP) to the learning and memory of mice. Key findings: Both 17 nm and 37 nm GNPs induced severe sickness in mice. However, only 17 [...]

Nanotoxicity Assessment toward the Applications of Carbon Nanotubes as a Small Biomolecule Carrier in Drug Delivery Systems

Sharma A., Sharma R., Kwon S., Baktur R., Sharma A., Sharma R., Utah State University, US

Carbon Nanotube (CNT) materials has superior properties in electric current carrying capacity, thermal conductivity, and thermal stability. Due to their structure with high aspect ratio, they have structural unusual toxicity and complicate safety issue in [...]

Cytotoxicity of metallic oxide nanoparticles in human neural and non-neural cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy & Biomedical Research Institute, US

The use of nanomaterials in industrial applications (e.g., drug delivery, additives to drugs and cosmetics) has escalated in the last decade, leading to the possibility of their becoming environmental pollutants. However, these cytotoxic and other [...]

A Non-Contact Culture Model for Investigating Cell Signaling and Nanotoxicity

Gao W.J., Dukhande V.V., Jandhyam S., Wang Y.-H., Gu H.-Y., Lai J.C.K., Lai M.B., Lai J.C.K., Lai M.B., Leung S.W., Idaho State University, US

There is general agreement that in vitro cell model systems offer many advantages over in vivo model systems in elucidation of cell signaling and other mechanisms underlying a toxicant’s effect. While the 3-D cell models [...]

A Co-Culture Model for Nanotoxicity and Tissue Engineering Studies

Wang Y.-H., Jandhyam S., Dukhande V.V., Gao W.J., Gu H.-Y., Lai J.C.K., Lai M.B., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy & Biomedical Research Institute, US

Cell model systems in vitro play vital roles in recent advances in toxicological and tissue engineering research. They are particularly versatile in facilitating signaling and related mechanistic studies. Although the 3-D cell models better simulate [...]

Differential Cytotoxicity of Metallic Oxide Nanoparticles in Mammalian Cells

Lai J.C.K., Lai M.B., Jandhyam S., Dukhande V.V., Bhushan A., Daniels C.K., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University, US

Nanomaterials have been increasingly used in industrial applications (e.g., drug delivery, additives to drugs and cosmetics). Because of their wide use, occupational exposure to nanomaterials and nanoparticles may pose as health risks. Recent studies have [...]