microfluidics – Page 11 – TechConnect Briefs

Electrokinetic and Hydrodynamic Focusing/Switching in Microfluidics

Yang R-J, Chang C-C, Huang S-B, Lee G-B, National Cheng Kung University, TW

This paper presents an investigation on hydrodynamic/electrokinetic focusing and switching, which are crucial for microfluidic applications. The hydrodynamic/electrokinetic focusing phenomenon is first theoretically modeled by employing a potential flow theory, and this simple theoretical model [...]

Electrokinetic Instabilities and Sample Stacking

Lin H., Oddy M.H., Santiago J.G., Stanford University, US

Microfabrication technology has enabled the application of electrokinetics as a method of performing chemical analyses and achieving liquid pumping in electronically-controlled microchip systems with no moving parts. This talk reviews progress at Stanford in the [...]

Applications of Topology Optimization in the Design of Micro- and Nanofluidic Systems

Okkels F., Olesen L.H., Bruus H., Technical University of Denmark, DK

The material distribution method in topology optimization was developed in the late 1980ies for stiffness design of mechanical structures, and only recently the first steps have been taken towards implementing the method in fluidics. Topology [...]

Design Paradigms and Methodologies for Microfluidics

Hardt S., Darmstadt University of Technology, DE

This paper reviews and compares different strategies for designing and building up microfluidic systems, with a special emphasis on the system aspect as opposed to single components capable of performing only special operations. An overwhelming [...]

Enhancement of DNA Microarray Hybridization using Shear-Driven Microfluidics

Vanderhoeven J., Pappaert K., Dutta B., Vanhummelen P., Baron G.V., Desmet G., Free University of Brussels, BE

On microarrays the transport of the target molecules towards the spots only occurs by molecular diffusion. As a result, microarray analyses require overnight incubation and are highly inefficient in terms of capture rate and detection [...]

Numerical Modelling of a Microfluidic Ultrasonic Particle Separator

Townsend R.J., Hill M., Harris N.R., White N.M., Beeby S.P., University of Southampton, UK

Particles held in a fluid suspension and within an acoustic standing wave experience an acoustic radiation force. The force causes particles to move to the pressure nodes of the acoustic field creating a concentrate, contributing [...]

Highly Selective Capture and Transport of Rare Cells in Microfluidic Channels

Ward M.D., Grodzinski P., Los Alamos National Laboratory, US

Collection of rare target cells in clinical samples such as disseminated tumor cells in peripheral blood or fetal cells in maternal blood poses difficult challenges to currently available cell separation methods. A novel, two stage [...]

Chemotaxis of Metastatic Breast Cancer Cells in Parallel Gradient Microfluidic Chambers

Saadi W., Wang S-J, Lin F., Jeon N.L., University of California Irvine, US

Chemotaxis plays a key role in cancer metastasis, directing the motility of metastatic cells through gradients of growth factors or other chemoattractants. In order to rigorously characterize the role of growth factors in cancer cell [...]

UV Laser Micro-Materials Processing Of MEMS, Microfluidics, Sensors, LEDs and Other Miniature Devices

Sercel J.P., JP Sercel Associates, Inc., US

An overview of the types of UV laser processing as applied to the fabrication of miniature devices using advanced UV Excimer and UV DPSS lasers, will be presented. This discussion will include examples of high [...]

A Numerical Algorithm for Complex Biological Flow in Irregular Microdevice Geometries

Trebotich D., Colella P., Miller G.H., Nonaka A., Marshall T., Gulati S., Liepmann D., Lawrence Livermore National Laboratory, US

We present a numerical algorithm to simulate non-Newtonian flow in complex microdevice components. The model consists of continuum viscoelastic incompressible flow in irregular microscale geometries. Our numerical approach is the projection method of Bell, Colella [...]