microfluidics – TechConnect Briefs

Flexible Microfluidics-Integrated Organic Transistor as Biofeedback for Advanced Wound Healing

Heidrich J., Oh K.W., The State University of New York at Buffalo, US

This paper will discuss how incorporating a biofeedback sensor into an electrical stimulation bandage used on chronic ulcers will improve the healing process. Current wound healing devices, and specifically wearable ones, are an open loop [...]

Computational Fluid Dynamics Models for the Rational Design of Magnetic Microseparators – In Memory of Dr. Ed Furlani

, The Ohio State University, US

In this work, we report a numerical flow-focused study of bead magnetophoresis inside a continuous-flow microchannel in order to provide a detailed analysis of bead motion and its effect on fluid flow. Different Computational Fluid [...]

New Technologies for the Rapid Identification of Drug-Resistant Bacteria

Sauer-Budge A.F., Exponent and Boston University, US

The extensive use of antibiotics to treat infections, without first specifically identifying the underlying cause, has resulted in a strong natural selection for antibiotic resistant organisms. Conservative estimates from the CDC indicate that more than [...]

Mimicking Proximal Tubule Cell functioning for Artificial Kidney Applications

Sateesh1 J., Guha K., Dutta A., Sengupta P., Srinivasa Rao K., National Institute of Technology Silchar, IN

The importance for artificial organs development is ever increasing, especially for artificial kidney is needed by a vast number of people suffering from kidney failure. This paper presents a novel Bio-reactor technique by using the [...]

Recirculating samples inside chambers using vacuum and centrifugal forces

Wang A., Koh D., Oh K.W., SMALL (Sensors and MicroActuators Learning Lab), Department of Electrical Engineering, The State University of New York at Buffalo, US

In this paper, a combination of vacuum and centrifugal forces was studied for recirculate samples inside the chambers. Detection low concentration samples, rare molecules such as cancer cells or certain proteins among large volume of [...]

Optimization of continuous-flow magnetic bioseparators through CFD numerical models

González-Fernández C., Gómez-Pastora J., Karampelas I.H., Bringas E., Ortiz I., The Ohio State University, US

Continuous flow bioseparators allow magnetic particles that are properly functionalized so that they get attached to dangerous pathogens. Specifically, the unique properties of magnetic particles enable their separation from blood, after fulfilling their role of [...]

Companion diagnostic test using digital microfluidic

Fouillet Y., Den Dulk R., Fuchs O., Boizot F., Menneteau M., Navarro F., CEA-LETI, FR

Companion diagnostics are an indispensable part of personalized medicine, providing information that is essential for the safe and effective use of a corresponding therapeutic drug. Such devices need to be robust, transportable and easy to [...]

Microfluidic Test Target for Photoacoustic Imaging

Schneider P., Eadie N., Christie L., Zhan Y., Siskar T., Koh D., Xia J., Oh K.W., University at Buffalo's Sensors & MicroActuators Learning Lab (SMALL), US

Photoacoustic imaging involves the use of optics (typically a high power pulsed laser) and acoustics (ultrasonics frequency ranges >1MHz) to image a targeted object. Individually, these modalities, being optical and ultrasonic imaging, can be quantified [...]

The Development of an Optofluidic Evanescent Field Sample Trapping and Loading Solution for Time Resolved Protein Crystallography Experiments

Diaz A.J., Docker P., Sparkes M.R., Kay J., Stuart D., Beale D. Axford J., ONeil W., Cordovez B., Diamond light Source, UK

X-ray crystallography is the leading technique for determining the atomic structure of biological molecules. The developers of this technique have maintained this position by continuously pushing the hardware and software boundaries such that data-collection from [...]

Numerical Investigation Of Rigid Microparticles Dynamics: Aggregation And Clogging Phenomena In Microfluidics By Discrete Element Method (DEM) And CFD Coupling

Shahzad K., Van Aeken W., Kamyab V.K., Mottaghi M., Kuhn S., KU Leuven, BE

Microfluidics has achieved a positive response in the industrial sector in the last two decades, i.e., due to its minute size plus control over all the chemical and physical properties at various flow rates (Re~1-10) [...]