Mimicking Proximal Tubule Cell functioning for Artificial Kidney Applications

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The importance for artificial organs development is ever increasing, especially for artificial kidney is needed by a vast number of people suffering from kidney failure. This paper presents a novel Bio-reactor technique by using the size dependent reabsorption of the proximal convoluted tubule. The modelling, simulation and analysis are carried- out to optimize the flow in the proposed structure. The analytical formulae developed are considered and a model has been built in FEM tool. The total volumetric flow through straight channels is 0.63×10-16 which comparatively less than slant channels 0.72×10-16 The obtained simulated results have good correlation with analytical analysis. Finally, the shape of main tubule has been analysed with two different shapes straight and Diagonal. The straight tubule is considered for its ease of practical realization and acceptable flow velocity.

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Journal: TechConnect Briefs
Volume: TechConnect Briefs 2019
Published: June 17, 2019
Pages: 306 - 309
Industry sector: Sensors, MEMS, Electronics
Topics: Nanoelectronics, Sensors - Chemical, Physical & Bio
ISBN: 978-0-9988782-8-7