drug delivery – Page 4 – TechConnect Briefs

Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular deliery of doxorubicin

Saravanakumar G., Shin J.M., Um W., Park J.H., Sungkyunkwan University, KR

Disulfide-containing HA dodecyl conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction as the carrier for intracellular delivery of doxorubicin (DOX). Owing to its amphiphilicity, HA-SS-DDT could form self-assembled nanoparticles in an aqueous condition. The [...]

NanoBandage for Controlled Release of Topical Therapeutics

Patchan M., Calderon-Colon X., Benkoski J., Theodore M., Le H., Fuller B., Boggs N., Nelson A., Garza L., Sarkar K., Brandacher G., Patrone J., The Johns Hopkins University Applied Physics Laboratory, US

Burn injuries, trauma, and surgical procedures result in complex wounds, which can lead to pain, infection, and scarring. Management of complex wounds remains a critical challenge for the medical community and effective, localized treatments are [...]

Magnetic Field-Induced Cyclizations of Amino-Esters and -Carbonates Bound to Iron Oxide Nanoparticles

Knipp R.J., Uradu O., Nantz M.H., University of Louisville, US

We studied a panel of thermally sensitive amino-esters and amino-carbonates to evaluate their cyclization rates on heating. After analyzing the influence of chain length, steric factors, gem-dimethylation and additional functionalities, we have determined which ester [...]

Exploiting the “protein corona effect” for targeted drug and gene delivery

Caracciolo G., Pozzi D., Capriotti A.L., Cavaliere C., Cardarelli F., Salomone F., Laganà A., Sapienza University of Rome, IT

When administered in vivo lipid nanoparticles (NPs) are immediately covered by a rich protein layer, known as “protein corona” that changes the size, aggregation state, and interfacial properties of the NP, giving it a biological [...]

Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (–) prostate cancers

Jo H., Ban C., Pohang University of Science and Technology, KR

We have designed a dual-aptamer complex specific to both prostate-specific membrane antigens (PSMA) (+) and (–) prostate cancer cells. In the complex, an A10 RNA aptamer targeting PSMA (+) cells ¬¬and a DUP-1 peptide aptamer [...]

Surface Structure of the drug delivery liposome

Magarkar A., University of Helsinki, FI

The criteria for effectiveness of drug delivery liposomes (DDLs) are structural stability, site specific targeting, and lifetime in the bloodstream. Often to increase the lifetime in bloodstream DDL is coated with poly ethylene glycol (PEG). [...]

In vitro anticancer activity of poly(3-hydroxybutyrate) nanoparticles loaded with antitumor drug Paclitaxel

Yakovlev S.G., Bonartsev A.P., Bonartseva G.A., Bagrov D.V., Efremov Yu.M., Boskhomdzhiev A.P., Filatova E.V., Ivanov P.V., Makhina T.K., Bonartseva G.A., A.N.Bach’s Institute of Biochemistry Russian Academy of Sciences, RU

We have produced nanoparticles loaded with antitumor drug paclitaxel. Operated nanospheres were prepared on the base of a biodegradable and biocompatible polymer of bacterial origin, poly(3-hydroxybutyrate) (PHB). PHB nanoparticles with paclitaxel (230±55 nm in diameter) [...]

Keywords: drug delivery