DNA – Page 7 – TechConnect Briefs

Stochastic Analysis of Particle-Pair Transport in Brownian Ratchet Device

Retkute R., Gleeson J.P., University College Cork, IE

The motion of particle pairs in a Brownian ratchet device is studied using Langevin simulations. A Lennard-Jones interaction between the particles is added to a standard spring-bead model. The effects of such interaction upon a [...]

Sample-Shunting Based PCR Microfluidic Device

Auroux P-A, Day P.J.R., Manz A., Imperial College, UK

A new method to perform on-chip DNA amplification is presented in this abstract: we shunt the sample back and forth over temperature-controlled zones. Compared to existing systems, this approach offers, in addition to a greater [...]

High-Resolution Electrochemical In Situ Printing

Egeland R.D., Southern E.M., Oxamer & Oxford Gene Technology, UK

This work demonstrates a new method for making oligonucleotide microarrays by synthesis in situ. The method uses conventional DNA synthesis chemistry with an electrochemical deblocking step. Acid is delivered to specific regions on a glass [...]

Detection of DNA Hybridyzation with Impedance Amplifying Labels

Ma K-S, Madou M., Zhou H., Fischetti A., Zoval J., Madou M., University of California Irvine, US

Traditionally used nucleic acid analysis detection platforms rely on fluorescent or radioactive labels. Optical techniques require large and expensive equipment such as automated colorimetric and fluorimetric instruments that greatly increase the cost of the whole [...]

STM/STS Studies of SWNTs in Bundles, C60 Thin Films and DNA Molecules

Maruyama Y., Ikeda K., Suzuki K., Yoshikawa T., Kato T., Iijima M., Hosei University, JP

The electronic structures of individual carbon nanotubes in a bundle are characterized by STM/STS technique. It is statistically found that the tubes with the same character tend to be assembled in one bundle and its [...]

Effects of Backbone Disorder on Electronic Transport in DNA Molecules

Zhong J.X., Oak Ridge National Laboratory, US

A minimal model was recently proposed to explain the gap opening and the semi-conductor behavior in poly(G)-poly(C) DNA molecules. In this model, the large band gap is attributed to the hybridization of the G-G p [...]

PCR Micro-Voume Device for Detection of Nucleic Acids

Auroux P-A, Day P., Niggli F., Manz A., Kinderspital, CH

The polymerase chain reaction (PCR) is an enzyme-mediated nucleic acid amplifer process that is employed extensively throughout the medical and biological sciences. The technique has risen to acclaim largely through its exquisite sensitivity, but an [...]

Molecular Electronics: The Experimentalist’s View

Tsui R., Motorola, US

In the last few years, significant experimental advances have been achieved in the utilization of nanoscale molecular components for electronic applications. A variety of materials, including carbon nanotubes, custom-synthesized organic molecules, metallic nanoparticles, and biological [...]

Macromolecules in Microdevices: Multiscale simulation of DNA dynamics in model microfluidic geometries

Jendrejack R.M., de Pablo J.J., Graham M.D., University of Wisconsin-Madison, US

Simple arguments predict that the dynamics of a dissolved macromolecule confined to a channel comparable to its equilibrium coi size (~1 um for viral DNA) are quite different from those in free solution, because of [...]

Separation of Long Polyelectrolytes in a Microfuluidic Channel with Constrictions: A Monte Carlo Study

Tessier F., Slater G.W., University of Ottawa, CA

We present Monte Carlo simulation results for the motion of long linear polyelectrolytes inside a microchannel of molecular dimensions, structured as a periodic array of wells linked by narrow constrictions. Molecules are driven in the [...]