DNA – TechConnect Briefs

Large scale Manufacturing of Calcium Phosphate Nanoparticles for Medical Applications

Panagiotou T., Delphi Scientific, US

Calcium phosphate (CaP) nanoparticles find medical applications in a number of areas, including delivery of nucleic acid therapeutics and calcium-based tissue engineering. CaP is well-studied biocompatible, bioactive, and bioabsorbable material and is used extensively in [...]

An Enzyme-Responsive Controlled Release Drug Delivery System Based on Mesoporous Silica and DNA

Zhang X., Wu Z., Hefei Institutes of Physical Science, Chinese Academy of Sciences, CN

An efficient enzyme-responsive controlled release drug delivery system was fabricated using functional mesoporous silica nanoparticles (FMSN) encapsulated with the single-stranded DNA. Based on the electrostatic interactions between FMSN and single-stranded DNA, the DNA coating could [...]

Neutron Scattering for Biological Research: Progress at the Bio-SANS Beam Line

Qian S., Pingali S.V., Weiss K., Urban V., O'Neill H.M., Langan P., Oak Ridge National Laboratory, US

Structure-function relationships remain a critical theme in understanding many important biological processes regarding energy, disease and other applications. At Oak Ridge National Laboratory, home to two of the most powerful neutron sources for research High [...]

Effective Multistep Exciton Delivery Through DNA-based Photonic Wires

Spillmann C.M., Buckhout-White S., Ancona M.G., Cunningham P.D., Melinger J.S., Goldman E.R., Medintz I.L., Naval Research Laboratory, US

Energy manipulation at the nanoscale is a key requirement to develop next-generation nanotechnologies ranging from biosensing to light harvesting, yet the design rules of these nanoscale systems must first be optimized to accomplish their intended [...]

DNA Double-Write Photolithography: A Synergy for Top-Down and Bottom-Up Nanofabrication

Heller M.J., Song Y., University of California San Diego, US

Intrinsic programmability and other unique properties of DNA allow it to be used as a self-assembly nanostructure material, easily functionalized with nanoparticles and other entities, and as a UV sensitive write material for patterning. Thus, [...]

Improving the sensitivity of Pedot:Pss modified gold electrode using gold and silver nanoparticles for Ganoderma boninense DNA detection

Dutse S.W., Yusof N.A., Ahmad H., Hussaini Adamu Federal Polytechnic, NG

The sensitivity of a designed electrochemical DNA biosensor was improved using gold and or silver nanoparticles. A gold electrode modified with a conductive nanocomposite of poly(3,4-ethylenedioxythiophen)–poly(styrenesulfonate) (Pedot-Pss) and gold or silver nanoparticles enhanced the conductivity [...]

Dielectrophoretic Isolation and Detection of Cancer Related DNA and RNA Nanoparticulate Biomarkers from Blood and Plasma

Heller M.J., Marciniak J., Skowronski E., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA and RNA nanoparticulate biomarkers continues to become more widely used for cancer diagnostics and management. Generally, cfc-DNA for “liquid biopsies” is isolated form plasma using relatively long [...]

Real-time monitoring of pathogens and nanomarkers in water by resonance laser spectroscopy techniques

Moguilnaya T.Yu., Bobkov P.V., Tomilin V.A., Kononenko E.B., JSC “SERVET-M”, RU

We develop a new method, allowing real-time monitoring of pathogens and DNA in water. The method is based on an analysis of radiation spectra in near-IR region. We have applied this method for rapid analysis [...]

Real-time monitoring of pathogens and nanomarkers in water by resonance laser spectroscopy techniques

Moguilnaya T.Yu., Bobkov P.V., Tomilin V.A., Kononenko E.B., JSC “SERVET-M”, RU

We develop a new method, allowing real-time monitoring of pathogens and DNA in water. The method is based on an analysis of radiation spectra in near-IR region. We have applied this method for rapid analysis [...]

Mechanism and Free Energy of DNA Hybridization on Single-Walled Carbon Nanotubes Using Adaptive Biasing Force Simulations

Chien M.W., Johnson Jr. A.T.C., Johnson R.R., Pillai S., Singh S.R., Johnson Jr. A.T.C., Johnson R.R., University of Pennsylvania, US

DNA-carbon nanotube hybrids (DNA-NT) consist of single stranded DNA self-assembled to the sidewall of single-walled carbon nanotubes. DNA-NT show great promise for applications in nanotechnology, including chemical sensing and sequence-specific DNA detection. Details of the [...]