dendritic cells – TechConnect Briefs

PLA-PEG nanoparticles are suitable for effective maturation and uptake by dendritic cells for Chlamydia trachomatis outer membrane peptide-based vaccine

Dixit S., Sahu R., Singh S.R., Dennis V.A., Alabama State University, US

Chlamydia trachomatis is considered an important human pathogen because it is the most reported sexually transmitted bacterial infection globally. We showed that M278 (a peptide derived from the major outer membrane protein of C. trachomatis) [...]

SiRNA for Therapeutic Immuno-modulation: Simultaneous Delivery of Cytokine-targeted SiRNA and DNA Antigens to Dendritic Cells using Polymer Microcarriers

Singh A., Nie H., Ghosn B., Roy K., The University of Texas at Austin, US

RNA interference mediated gene knockdown is a potential immuno-modulatory tool for tuning dendritic cells (DC) activation and function in-vivo. We have developed a novel multi-tiered delivery system for combinatorial administration of SiRNA and plasmid DNA [...]

The Effect of Gold Nanoparticles on Dendritic Cells

Vallhov H., Qin J., Johansson S., Muhammed M., Gabrielsson S., Scheynius A., Karolinska Institutet, SE

Recent biological applications have been focusing on using gold nanoparticles for e.g. drug and gene delivery. There is however little information available concerning what influence such particles have on the immune system, e.g. on dendritic [...]