controlled release – TechConnect Briefs

Yeast Cell Wall Particle Encapsulation of Pro-Terpene Payloads

Soto E., Rus F., Ostroff G., University of Massachusetts Medical School, US

Terpenes are naturally occurring compounds produced by plants that have long been recognized for their insecticidal, antimicrobial, and antioxidant properties. However, applications of terpenes have been limited by their volatility and poor water solubility resulting [...]

Bilayer coated ureteral stent as drug delivery platform to treat ureteric diseases

Lim W., Xiong G.M., Chong T.W., Huang Y., Venkatraman S., Nanyang Technological University, SG

The current methods of treating ureteric diseases such as strictures and carcinoma include endoscopic full-thickness incision of the ureteric wall and placement of an indwelling stent for up to 6 weeks. However, such interventions are [...]

Alginate/Montmorillonite nancomposites for the delivery of curcumin

Ramadan A.R., Ahmed M., The American University in Cairo, EG

Curcumin is a well-known traditional medicine with anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been studied to investigate its use in clinical and therapeutic applications. However, its low water solubility [...]

An Enzyme-Responsive Controlled Release Drug Delivery System Based on Mesoporous Silica and DNA

Zhang X., Wu Z., Hefei Institutes of Physical Science, Chinese Academy of Sciences, CN

An efficient enzyme-responsive controlled release drug delivery system was fabricated using functional mesoporous silica nanoparticles (FMSN) encapsulated with the single-stranded DNA. Based on the electrostatic interactions between FMSN and single-stranded DNA, the DNA coating could [...]

Controlled Release Polymers for Remediation of Contaminated Groundwater

Carpenter A., Gause C., Luster-Teasley S., AxNano, US

The EPA estimates that one out of every four Americans lives within three miles of a hazardous waste site. Over 450,000 brownfield sites are awaiting remediation with 1,280 sites on the National Priorities List (NPL). [...]

Abuse Prevention by Controlled Release of Opioids from Micro to Nano-structured Silica Xerogel Delivery Systems

Toworfe G., Anku C., Radin S., Zeiger A., Ducheyne P., Flowers Sch of Technology & Management, DE

This study proposes that release concentrations, of opioid, not exceeding therapeutic target levels can be achieved by incorporating the dosage in a nano-structurally optimized delivery material.

Nitric oxide releasing PLGA microspheres for biomedical applications

Lautner G., Schwendeman S.P., Meyerhoff M.E., University of Michigan, US

In the current work, we encapsulated an S-nitroso species in biodegradable poly(lactic-co-glycolic acid (PLGA) microspheres (with diameter of 20-125 µm) that release nitric oxide (NO) for weeks in a continuous and controlled manner. The rate [...]

Applying Plasmon Resonant Coating to Commercial Liposomal Delivery Systems

Knights-Mitchell S.S., University of Arizona, US

Multiple drug-encapsulated liposomes have been successfully marketed as pharmaceuticals within the past two decades. Some of these liposomal drugs have been shown to selectively localize within tumors. However, one limitation is the inability to control [...]

Magnetic Field-Induced Cyclizations of Amino-Esters and -Carbonates Bound to Iron Oxide Nanoparticles

Knipp R.J., Uradu O., Nantz M.H., University of Louisville, US

We studied a panel of thermally sensitive amino-esters and amino-carbonates to evaluate their cyclization rates on heating. After analyzing the influence of chain length, steric factors, gem-dimethylation and additional functionalities, we have determined which ester [...]

Nano Graphene Oxide as Drug Carrier for Antihypertensive Agent: Benazepril, Captopril and Losartan

Wang J., Long Y., Tao C., Liu H., Zhu H., Zhou X., National University of Defense Technology, CN

Graphene oxide (GO) offers large surface and novel biocompatible properties that are currently being explored for advanced drug carriers. GO has a one-atom-thick two dimensional carbon system, which contains several kinds of oxygen functional groups [...]