Nano Graphene Oxide as Drug Carrier for Antihypertensive Agent: Benazepril, Captopril and Losartan

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Graphene oxide (GO) offers large surface and novel biocompatible properties that are currently being explored for advanced drug carriers. GO has a one-atom-thick two dimensional carbon system, which contains several kinds of oxygen functional groups on its basal planes and edges. Benefit from its great surface area, well-dispersion, novel biocompatible and lots of π-π stacking and H-bonding site, GO become a promising nano material as a drug carrier substance. Here we report nano GO as drug carriers and investigate its drug loading and release properties for Benazepril, Captopril and Losartan , which are used for antihypertensive treatment with short action time and poor water solubility. The loading capacity depends on the initial ratio of drug/GO ratio. The max loading of these three drugs are 1.12 mg/mg (Benazepril), 0.49 mg/mg (Captopril) and 0.30 mg/mg (Losartan) respectively.The release behaviors of these three drugs are pH-depended. The total amount of drug released in acidic environment is high than any other pH value. The pH-depended release property is due to the partial dissociation of hydrogen-bonding interaction under different pH conditions. The pH-dependent release property makes it possible to release drugs at determined target organs with different pH such as stomach and intestines.

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Journal: TechConnect Briefs
Volume: 1, Nanotechnology 2013: Advanced Materials, CNTs, Particles, Films and Composites (Volume 1)
Published: May 12, 2013
Pages: 239 - 242
Industry sector: Advanced Materials & Manufacturing
Topics: Carbon Nano Structures & Devices, Graphene & 2D-Materials
ISBN: 978-1-4822-0581-7