US – Page 53 – TechConnect Briefs

The OsteoAccess System – Low-Force, Controlled Angled Bone Access for Bone Biopsy and Bone Marrow Aspiration

Mulvihill M.L., Ashuckian E.D., Greaser J.K., Hartung K.M. Erdley H., Bagwell R.B., Actuated Medical Inc, US

Many medical procedures and diagnostics require penetrating hard cortical bone. For example, biopsies and aspirates taken from within bone are used to diagnose a wide range of cancer and blood diseases. Sampling locations can include [...]

The Detection of PETN Using a Bulk Single Wall Carbon Nanotube/Peptide System

Kubas G., Rees W., Caguiat J., Asch D., Fagan D., Cortes P., Youngstown State University, US

The present research work investigates the novel detection of pentaerythritol tetranitrate (PETN), a high powered explosive, using peptide surface functionalized single wall carbon nanotubes. Here, through the use of a phage display technique and enzyme-linked [...]

Effect of silver coated carbon nanotubes on metabolically essential gene expression and outer membrane protein profile of Escherichia coli

Chaudhari A.A., Singh S.R., Pillai S., Alabama State University, US

Antibiotic resistance acquired by food borne pathogens such as E. coli has become a global concern. Recently, nanoparticles have been shown to be effective alternatives to antibiotics. Specifically, silver coated carbon nanotubes (AgCNTs) have been [...]

Gold Nanorods Induce Innate Immune Response and Reduce Respiratory Syncytial Virus Replication

Bawage S., Tiwari P., Singh A., Singh S., Dixit S., Pillai S., Dennis V., Singh A., Singh S., Alabama State University, US

Metallic nanoparticles (MNPs) have been used for diverse applications like sensing molecules, diagnosis of cancer, delivery of drugs and vaccines. Among the various MNPs, the gold nanorods (GNR) have been commonly used for such diagnosis [...]

Technological Challenges and Potential Advantages of Lipobeads as Drug Delivery Systems

Kazakov S., Pace University, US

Both polymeric and liposomal drug delivery systems tend to develop in the direction of increasing complexity, i.e. in accord with our understanding of the complex biological mechanisms prevailing in situ. To this point, one can [...]

Novel method for topical and transdermal delivery of Nanomaterials

Kalghatgi S., Juluri A., Stone S., Gray R., EP Technologies LLC, US

Nanoscale drug delivery systems including, but not limited to nanoparticles, liposomes, nanotubes, quantum dots, could potentially revolutionize modern drug delivery systems. Nanomaterials have wide applications in pharmaceutical sciences including their use in drug delivery as [...]

Ferromagnetic Gd5Si4 Nanoparticles for Medical Applications

Forney C., Iowa State University, US

The Gd5(SixGe1-x)4 system has been widely studied in the bulk form, but synthesis of nanoparticles of the material have never been reported. Iowa State University researchers have developed a process to fabricate ferromagnetic submicrometer Gd5Si4 [...]

In vitro reduction of mycotoxins and other inflammatory mediators from whole blood using CytoSorb® hemoadsorbent polymer beads

Scheirer A.R., Rueggeberg K.-G., Golobish T.D., Guliashvili T., Gruda M.C., O’Sullivan P., Chan P.P., CytoSorbents Corporation, US

Opportunistic fungal infections account for up to 25% of all hospital-acquired blood infections. Patients at highest risk are those with weakened immune systems, and include elderly patients, patients with cancer or HIV infection, and patients [...]

Comparing Biocompatibility of Titanium Orthopaedic Implants With and Without an Ultra-thin Coating of TiO2 by Ion Beam Assisted Deposition

Miralami R., Namavar F., Thiele G.M., Sharp J.G., Garvin K.L., University of Nebraska Medical Center, US

Introduction: Annually, more than one million Americans undergo arthroplastic surgeries, and by 2030 the projected number will exceed more than four million [1]. Thus, there is a serious need to accommodate such overload. It has [...]

A synergistic approach to the design, fabrication and evaluation of 3D printed micro and nano featured scaffolds for vascularized bone tissue repair

Holmes B., Bulusu K., Plesniak M., Zhang L.G., Nanochon LLC, George Washington University, US

In recent years, 3D printing has become a popular and widely investigated method for the fabrication of large bone implants. 3D printed bone constructs, devices and treatments hold great potential to repair traumatic and chronic [...]