KR – Page 42 – TechConnect Briefs

Sirna Nanomedicines for Cancer Gene Therapy

Kim S-H, Park T.G., Korea Advanced Institute of Science and Technology, KR

We developed a polyelectrolyte complex (PEC) micelle-based delivery system for treatment of prostate cancer. A PEGylated siRNA targeting human vascular endothelial growth factor (hVEGF) was synthesized. The hVEGF expression was almost completely inhibited in vitro [...]

Nano-Surface Behavior of Osteoblast Cell-Cultured Ti-30(Nb,Ta) with Low Elastic Modulus

Choe H.C., Ko Y.M., Brantley W., Chosun University, KR

Ti and Ti-alloys have good biocompatibility, appropriate mechanical properties and excellent corrosion resistance. However, the widely used Ti-6Al-4V is found to release toxic ions (Al and V) into the body, leading to undesirable long-term effects. [...]

Effects of Zr Content on the Electrochemical Characteristics of Nano-Structure Controlled Ti-alloys

Oh M.Y., Choe H.C., Ko Y.M., Park S-J, Brantley W., Chosun University, KR

Objective: Pure Ti as well as Ti-6Al-4V alloy exhibit excellent properties for dental implant applications. However, for a better biocompatibility it seems important to avoid in the composition the presence of V due to the [...]

Mechanical Properties of Nano-Structure Controlled Ti-Hf Alloy for Dental Implant

Jeong Y.H., Choe H.C., Ko Y.M., Park S-J, Kim D.K., Brantley W., Chosun University, KR

Objectives: Cp-Ti has a excellent biocompatibility. So, it was widely used dental implants and artificial joint. But it is not strong enough for some dental applications. Since Hf belongs to the same group as Ti [...]

Biocompatibilities of some synthetic polymers in films

Kim G., Kim H., Yoon J., Ree M., Kim G., Kim H., Pohang University of Science and Technology, KR

Materials for artificial devices require biocompatibility with the human body. Moreover, it has been well known that the implants are facilely tainted with pathogenic bacteria during surgical processes and that a few bacteria circulate in [...]

Characterization on Dioxin Emission of TiO2 Nanoparticle-Encapsulating Poly(vinyl chloride) (TEPVC) compared to conventional PVC

Yoo H., Kim S-H, Lee A.R., Kwak S-Y, Seoul National University, KR

In our previous study, we first prepared TiO2 nanoparticle-encapsulating poly(vinyl chloride) (TEPVC) aiming at breakthrough to enhance the dispersibility of TiO2 nanoparticles in PVC matrix to maximize catalytic activities of TiO2 nanoparticles. The present study [...]

Silver Particle and Silver Thiolate-Based Molecular Sensing/Recognition Units Operating via Surface-Enhanced Raman Scattering

Kim K., Kim N.H., Park H.K., Kim K., Kim N.H., Lee H.S., Lee Y.M., Lee H.S., Lee Y.M., Seoul National University, KR

Noble metallic nanostructures exhibit a phenomenon known as surface-enhanced Raman scattering (SERS) in which the scattering cross sections are dramatically enhanced for molecules adsorbed thereon. We demonstrate that commercially available Ag(μAg) powders can be used [...]

Label-Free Protein Nano-Biosensor Using Top-Down Fabrication

Ah C.S., Ahn C-G, Kim A., Yu H.Y., Ahn C-G, Yang J.H., Baek I-B, Park C.W., Jun M.S., Lee S.J., Electronics and Telecommunications Research Institute (ETRI), KR

A nanosensor of n-type Si field-effect transistor (FET) via “top-down method” was employed to monitor PSA with great selectivity and high sensitivity up to 10 pg/mL. When a biomaterial, negatively charged PSA, is introduced through [...]

DNA-DNA Interaction on Dendron-Functionalized Sol-Gel Silica Films Followed with Surface Plasmon Fluorescence Spectroscopy

Kwon S.H., Hong B.J., Park H.Y., Park J.W., Knoll W., Park H.Y., Park J.W., Center for Integrated Molecular System., KR

Since we observed that dendron-assembled surface providing a proper spacing between immobilized DNAs showed high single nucleotide polymorphism discrimination efficiency for DNA microarrays(1), the nanoscale-controlled surface is examined with surface plasmon field-enhanced fluorescence spectroscopy (or [...]

New carrier for protein and drug delivery based on injectable Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) pH/temperature hydrogel

Lee D.S., Huynh D.P., Sungkyunkwan University, KR

Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) - a novel pH/temperature sensitive and biodegradable hydrogel copolymer used for drug and protein delivery was synthesized. Bovine insulin (BI) and human growth hormone (HGH) loaded well to the copolymer [...]