A nanosensor of n-type Si field-effect transistor (FET) via “top-down method” was employed to monitor PSA with great selectivity and high sensitivity up to 10 pg/mL. When a biomaterial, negatively charged PSA, is introduced through a fluidic channel, the conductivity of FET is lowered than that in pure buffer solution from the n-type nature of nanochannel as a bionanosensor. The Si FET bionanosensor allows a real-time monitoring without any labeling, which indicates this electrical property originated from the specific binding between antibody and antigen.
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Pages: 493 - 495
Industry sector: Sensors, MEMS, Electronics
Topics: Biomaterials, Chemical, Physical & Bio-Sensors