FR – Page 3 – TechConnect Briefs

Capillary flow of whole blood in microsystems: non-Newtonian blood behavior and substrate reagent-coating effect

Berthier J., Gosselin D., Huet M., Sabatte G., Cosnier M.L., Pouteau P., Cubizolles M., CEA-Leti (University Grenoble Alpes), FR

Introduction: The use of whole blood is a preferred solution for portable diagnostic and monitoring systems. We analyze here two particularities of microsystems for blood analysis: the blood non-Newtonian behavior, and the capillary flow in [...]

Drying Graphene Nanofluid on Heated Substrate

Chen P., University of Valenciennes, FR

With many extraordinary properties, especially the extremely high thermal conductivity, the graphene has potential applications in energy, electronic, medicine and so on. The addition of graphene nanoparticle to prepare water-based or ethylene-glycol-based nanofluid can significantly [...]

Droplet formation of highly viscous Newtonian and non-Newtonian fluids in a microfluidic flow focusing device: scaling of droplet size and production frequency

Authesserre C., Bottausci F., Costa G., Alessio M., Benhamou P-Y., Icard B., Rivera F., CEA-Leti Grenoble, FR

Polymer particles are largely used for different applications such as chromatography columns, calibration standards, drug delivery or cell encapsulation1. For all these applications, high size monodispersity and production frequency are required. Moreover, the polymers are [...]

Evaporation of Binary Mixture Nanofluid Drops: Pattern Formation

Parsa M., Harmand S., Sefiane K., Bigerelle M., University of Valenciennes, FR

After the complete evaporation of a sessile nanofluid drop, different deposition patterns can be formed on a substrate. The study of deposited patterns left after the drying of a drop containing suspensions has a significant [...]

Combined effects of pump and capillary pressures for the filling of microchannel networks: the difficulty of synchronization

Berthier J., Diakite M.L., CEA-Leti (University Grenoble Alpes), FR

In this work, we first propose a model for the filling of a capillary tube driven by a pressure pump. It is shown that the filling time depends not only on the pump pressure but [...]

Nanostructured lipid carriers as delivery systems of chemically grafted protein antigens

Bayon E., Morlieras J., Courant T., Gonon A., Marche P., Navarro F., CEA, FR

The development of vaccines was one of the major health advances of the last century. However, new vaccine formulations are still highly anticipated in the near future for facing some health challenges, such as the [...]

Development and Validation of Characterization Methods for Lipidots® Multifunctional Platform: a Step forward Industrial Transfer

Varache M., Ciancone M., Caputo F., Laffont C., Escudé M., Jary D., Boisseau P., Texier I., Navarro F.P., Couffin A.C., CEA-LETI, FR

For eight years, our research group has been developing lipid nanocarriers, known as Lipidots®, as a multifunctional platform for medical applications. A wide range of active pharmaceutical ingredients (APIs) and contrast imaging agents has been [...]

On the dynamic contact angle in spontaneous capillary flow

Berthier J., Gosselin D., Delapierre G., CEA-LETI, FR

Capillary actuation of fluids is an interesting solution when the gravitational forces are small: this is the case in space , or in microfluidic systems where gravity is negligible. The onset of spontaneous capillary flow [...]

Recent advances in capillary microflows for point-of-care and home-care devices

Berthier J., Gosselin D., Huet M., Cubizolles M., Delapierre G., CEA/LETI/MINATEC, FR

Biotechnology has been recently seeing fundamental evolutions: first, a clear shift towards biological applications; second a trend towards the design and fabrication of portable devices; third the choice of inexpensive materials such as plastic or [...]

Towards generic platforms for MEMS manufacturing

Rouzaud A., Polizzi JP., Robert P., Arcamone J., CEA-LETI, FR

Coming at the time of technical maturity, MEMS industry requires now more standardization in manufacturing processes. This paper presents Leti’s contribution to develop generic platforms matching the suitable MEMS technologies within two distinct fields: physical [...]