Papers:
A safer-by-design formulation concept for flame-generated engineered nanomaterials
Gass S., Pyrgiotakis G., Cohen J.M., Sotiriou G.A., Pratsinis S.E., Demokritou P., Harvard School of Public Health, US
As more consumers and factory workers become exposed to engineered nanomaterials (ENMs), the question of exposure risks is rapidly gaining importance. Engineering less toxic ENMs that maintain valuable functional properties is therefore crucial to the [...]
Titanium Dioxide Nanoparticles Interaction, Uptake and Genotoxicty in Salmonella typhimurium Bacteria
Due to their unique properties the use of nanoparticles (NPs) in consumer products is increasing rapidly. The expanding prevalence of NPs make it critical to understand the associated risk to both the public health along [...]
Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells
Tadinada S.M., Lai J.C.K., Lai M.B., Idikuda V.K., Mukka K., Singh M.R.M., Pfau J., Bhushan A., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy, US
Targeted drug delivery systems with minimal potential adverse/side effects are gaining utility in diverse applications. Uses of nanomaterials to design such targeted drug delivery are escalating exponentially. Nevertheless, the biocompatibility of nanomaterials is inadequately addressed. [...]
Cytotoxicity and biointeractions of nanosilver in macrophages
Pratsinis A., Pratsinis S.E., Hervella P., Leroux J.-C., Pratsinis A., Pratsinis S.E., Sotiriou G.A., ETH Zürich, CH
Silver nanoparticles (nanosilver) are broadly used today in textiles, food packaging, household devices and bioapplications, prompting a better understanding of their toxicity and biological interactions. Here, nanosilver of well-defined size (5.7 to 20.4 nm) supported [...]
Toxic Potential of Food-Relevant Nanoparticles in the Intestinal Epithelium
Oral exposure to nanoparticles incorporated in foods is increasingly common. However, the effects of these nanoparticles when ingested are still unknown. Thus, this investigation tested the hypothesis that nanoparticle toxicity is dependent on particle size, [...]
Oxidatively Induced Damage to DNA: Potential Roles of Single- and Multi-Wall Carbon Nanotubes at the Molecular Level
Carbon nanotubes (CNTs) are remarkable materials in terms of their enhanced thermal and electrical conductivities, tensile strengths and mechanical properties. Because of these unique properties, the commercial development and application of CNTs in electronics, advanced [...]
ROS Evaluation for Series of CNTs Using the ESR Method and the Effects of CNT Mophology
Tsuruoka S., Takeuchi K., Koyama K., Endo M., Fujisawa K., Matsumoto H., Saito N., Usui Y., Porter D.W., Castranova V., Shinshu University, JP
Carbon nanotubes (CNTs) are becoming important materials in industry. It is a concern that CNTs may induce carcinogenic responses through pulmonary exposure. It has been recently reported1-6 that CNTs scavenge ROS depending on their morphology. [...]
Entry of Short Multi-Wall Carbon Nanotubes into Dorsal Root Ganglion (DRG) Neurons Induces Cell Death
Lai J.C.K., Gao W., Bhushan A., Bearden S.E., McDougall L., Leung S.W., Idaho State University College of Pharmacy, US
Carbon nanotubes (CNTs) have found their way into diverse industrial and biomedical applications because of their unique physico-chemical properties. However, the human health impact of exposure to CNTs is unknown. Our recent and ongoing studies [...]
Bio-compatibility of silver nanomaterials using the embryonic zebrafish bioassay
The bio-compatibility of silver nanomaterials (AgNP) is currently of great interest to regulators and health and safety professionals because it is a material that has the potential to reach mass populations. Four well characterized (Harper [...]
“Just Add Water” – “Instant” singly-dispersed suspensions of silver nanoparticles on demand
The rapid pace of development of new nanomaterials and new applications has also attracted much attention from the environmental health and safety (EHS) risk assessment community. Subsequently, calls for well-characterized common test materials from a [...]
Quantitative Assessment of Nanoparticle Induced Oxidative DNA Damage Using Isotope Dilution Mass Spectrometry
Petersen E.J., Marquis B.J., Jaruga P., Dizdaroglu M., Nelson B.C., National Institute of Standards and Technology, US
Hyphenated mass spectrometry (gas chromatography/mass spectrometry) techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens and oxygen derived free radicals on the induction and [...]
Surface Chemical Transformations of UV Irradiated Silica-Epoxy Nanocomposites
Gorham J.M., Nguyen T., Bernard C., Stanley D., Holbrook R.D., National Institute of Standards and Technology, US
Silica nanoparticles (SiNPs) incorporated into a polymeric matrix, or silica nanocomposites (NCs), are used in a wide variety of commercially available products in numerous natural and artificial environments. Environmental factors, such as ultraviolet (UV) light, [...]
Analytical Strategies for a systematic Characterization of Nanoparticle Release from commercial Spray Products for Exposure Quantification and Risk Assessment
The characterization of nanoparticle release from consumer spray products is challenging. Therefore, we developed different analytical methods to determine quantity, morphology, size and elemental distribution for engineered nanoparticles in the original spray suspension and the [...]
Risk Ranking Framework to Assess the Health Hazard of Nanomaterial-Containing Products in an Industrial and Consumer Application Setting
The unique combination of size, structure, morphology, physical/chemical characteristics, and quantum properties of nanomaterials, presents a challenging platform in understanding the potential hazards and health risks of engineered nanomaterials and the products that utilize these [...]
Nanoparticle Characterization and Analysis of Airborne Titanium Dioxide in Powdered Cosmetics
In this study, several powdered cosmetic products were purchased and evaluated for the presence of TiO2 nanoparticles first by automated particle sizing using scanning electron microscopy (SEM) with chemical typing by energy dispersive spectroscopy (EDS) [...]
Analysis of Factors Associated with the Releasability of Carbon Nanotubes (CNTs) from Materials Containing Nanocomposites
Carbon nanotubes (CNTs)in composites are currently being used in applications ranging from basic consumer goods to critical national defense technologies; however, concerns have been raised regarding the potential for exposure and health risk CNTs due [...]
Inhibitory effects of titanium dioxide, silver and fullerene nanoparticles on activated sludge from a municipal wastewater treatment plant
The possibility of negative impacts of three nanomaterials on an aerobic heterotrophic microbial community (activated sludge) was investigated through respiratory inhibition tests (OECD 209 protocol). Titanium dioxide (TiO2NP, Evonik P25), silver (AgNP, synthesized in the [...]
Intelligent testing strategy for engineered nanomaterials
The exciting properties exhibited by nanomaterials have led to the development of vast numbers of different types of nanomaterials for a variety of applications. Such applications include medicines, cosmetics, clothing, food, food packaging, sporting equipment, [...]
Occupational Safety and Health Management Systems for the Safe Commercialization of Nano-enabled Products
The value of an occupational health and safety management systems (OHSMS) approach for the safe synthesis of engineered nanoparticles and safe commercialization of nano-enabled products will be presented. An OHSMS framework integrates continual H&S improvement [...]
Framework for Quantitative Exposure Assessment of Nanostructured Materials in Occupational Settings
The purpose of this work was to provide a framework for assessing potential for risk and exposure to nanostructured materials in occupational settings. In doing so, we evaluated the characteristics of amorphous silica and carbon [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: May 12, 2013
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Environmental Health & Safety of Nanomaterials
ISBN: 978-1-4822-0586-2