Aggressive conventional chemotherapy of solid cancers of the breast, lung, prostate, and colorectal area is severely limited by systemic toxic complications. New clinically practical concepts are needed for effective local therapeutic modalities. This paper reports [...]
Despite advances in drug retention and evasion of the body’s defenses, the therapeutic efficacy of many liposomes has been limited by low drug bioavailability within the tumor. Developed in this laboratory in 1996, lysolipid temperature [...]
IL-1, TNF-α and INF-γ cytokines stimulate in nitric oxide production and result with inflammation manifested by apoptosis and hypoxia. We propose that extent of inflammation leading to hypoxia initially and programmed cell death later both [...]
This work describes the formulation of a nanoparticle drug delivery system to co-administer a chemotherapeutic, paclitaxel, and an MDR modulator, C6-ceramide, aimed at overcoming multidrug resistance (MDR) of solid tumors. MDR can arise through several [...]
, Cao Z.
, Gao X.
, Karna P.
, Mao H.
, Nie S.
, Peng X.
, Staley C.
, Wang A.
, Wang X.
, Wood W.C.
, Yang L.
, Yuan Q.
, Emory University, US
We have engineered superparamagnetic iron oxide (IO) nanoparticles targeted to urokinase plasminogen receptors (uPAR), which is highly expressed in tumor cells, intratumoral fibroblasts and tumor endothelial cells and can also be internalized by cells. IO [...]
, DeNardo G.L.
, DeNardo S.J.
, Foreman A.R.
, Gruettner C.
, Ivkov R.
, Miers L.A.
, Natarajan A.
, Triton BioSystems, Inc., US
111In-ChL6 MAb-linked iron oxide nanoparticles (bioprobes) pharmacokinetics, tumor uptake and the therapeutic effect of inductively heating these bioprobes by an externally applied AMF were studied in athymic mice bearing human breast cancer HBT3477 xenografts. Bioprobe [...]
An analytical model is described for predicting the capture of therapeutic magnetic nanoparticles in the microvasculature. The particles consist of a magnetic core coated with surface-bound anticancer agents, and are directed to a tumor using [...]
We demonstrated the formation of oligonucleotide nanoparticle in the presence of polypropylenimine dendrimers using total intensity light scattering as well as AFM and TEM. Confocal microscopic analysis showed that the nanoparticles formed with G4 and [...]
Development of new technologies for reliable early detection of cancer from biological fluids via minimally invasive methods is still a high priority. Cancer cells often overexpress characteristic surface receptors, which provide an opportunity for early [...]
Coherent phase microscopy is a nanoscale measurement technique, an original method of monitoring the responses to cellular stress. We demonstrate that: 1) optically dense subcellular structures, including the nuclei and nucleoli, can be clearly detected [...]
Cancer development is a very complex process. Wide range of factors could contribute to the development of cancer. Factor that can lead to the development of cancer can range from oxygen free radicals to micronutrient [...]
Dielectrophoresis (DEP) is a phemomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and ananlysing the change in motion with frequency, [...]
MM has a unique molecular signature and is well suited as a model system for performing analysis on microchips. MM multiplex genetic analysis for clonotypic signatures and genetic abnormalities offers the possibility for genetic profiling [...]
Objective: The objective of the current study was to synthesize and modify thiolated gelatin nanoparticles with PEG chains, characterize, and evaluate their long circulating and tumor targeting potentials in vivo in a human breast cancer [...]
We have engineered a molecular nanosyringe that enables injection of molecules into a target cell at acidic pH, but not at normal, physiological pH. The injection is driven by a water-soluble peptide, pHLIP (pH (Low) [...]
For people dying of some cancers such as breast and prostate, the spread of bone cancer is almost universal. Although current drug delivery systems have found a variety of uses in targeting certain forms of [...]
Throughout various fields of science and technology, a push towards the use of nanoscale technology is well underway. One area where nanoscale work is already well underway is within the field of drug delivery.In this [...]
This research focuses on developing uniform particles with a Curie temperature that is similar to the therapeutic one for the purpose of cncer treatment. Such particles will self-regulate the temperature of the tumor during Magnetic [...]
, Feysulova R.A.
, Kogan B.Ya.
, Kvacheva L.D.
, Pankratov A.A.
, Puchnova V.A.
, Titov A.A.
, Vorozhtsov G.N.
, Yakubovskaya R.I.
, Organic Intermediates & Dyes Institute, RU
Light-absorbing nanoparticles incorporated in a tissue can be heated by short-pulsed laser irradiation up to several thousand Kelvin degrees. Average tissue temperature may be kept normal if the concentration of these particles is low. Antitumor [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 7, 2006
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topicss: Biomaterials, Cancer Nanotechnology