Bio Nano Materials – TechConnect Briefs

Vertically Aligned Patterned Peptide Nano Wires for Cellular Studies

Taskin M.B., Technical University of Denmark, DK

Over the years, scientific studies have shown that one crucial point when designing biological platforms is the strict environmental conditions required for cell and tissue culturing, such as pH, temperature, medium content and other parameters [...]

Synthesis of Ultra Small Biocompatible Magnetic Nanocomposites by Seeded Emulsion Polymerization

Kloust H., Pöselt E., Kappen S., Schmidtke C., Kornowski A., Pauer W., Moritz H.-U., Weller H., University of Hamburg, DE

We present the production of PEGylated particles in the lower nanometer range by a new seeded emulsion polymerization technique under micro-emulsion conditions, avoiding any treatment with high shear forces or ultrasonication. Hereby, the hydrophobic shells [...]

Unravelling adsorption and alignment of amyloid fibrils at interfaces by probe particle tracking

Isa L., Jung J-M, Mezzenga R., Jordens S, ETH Zürich, CH

We report the first direct, non-invasive experimental evidence of a 2D isotropic–nematic transition for highly anisotropic nanoparticles at liquid–liquid interfaces by using passive fluorescent particle tracking. In order to illustrate the potential of this approach [...]

Study on the novel drug vehicle with multimodal imaging function

Wu P.J., Liu T.Y., Institute of Biomedical Engineering, National Yang-Ming University of Taiwan (ROC), TW

Recently, in order to combine diagnosis with therapy in a single box, drug delivery systems (DDSs) associating with imaging functions were developed to improve the efficacy of diseases detection, delivery of therapeutic agents, and the [...]

Clusters of Iron Oxide Nanoparticles for Efficient Magnetic Resonance Imaging

Lai P.S., Lai S.M., Lai P.S., Lai S.M., National Chung Hsing University, TW

Recently, self-assembling clusters of metal nanoparticles have been extensively investigated in various fields. To prepare these clusters, various ionic surfactants, have been employed as stabilizers or emulsifiers to form water-dispersed spherical clusters. However, these ionic [...]

Multifunctional Micropatterned Nanofiber Capable of Cell Patterning, Metabolite Detection, and Growth Factor Delivery

Koh W.G., Lee H.J., Lee H.W., Lee H.J., Lee H.W., Park S., Yonsei University, KR

This study describes the development of multifunctional nanofiber scaffolds consisting of multiple layers of nanofiber scaffolds and nanofiber-incorporated PEG hydrogels. We fabricated double-layered nanofiber scaffolds that were micropatterned with PEG hydrogels by combining two-step sequential [...]

Boron Nitride Nanotubes functionalized with glucosamine as a potential novel carrier system for radioisotope and drug delivery

Ferreira Soares D.C., Ferreira T.H., Ferreira Soares D.C., Ferreira T.H., Costa-Moreira L.M., Martins Barros de Sousa E., Centro de Desenvolvimento da Tecnologia Nuclear, BR

In the present work, Boron nitride nanotubes (BNNTs) were synthesized and submitted to a functionalization process (coating) with glucosamine. The nanostructures were physicochemical and morphologically characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Raman [...]

Electronic effects in CdSe/ZnS quantum dots conjugated to Interleukin 10 antibodies

Torchynska T.V., Casas Espinola J.L., Douda J., López de la Luz O.S., Instituto Politecnico Nacional, MX

Photoluminescence (PL) and Raman scattering spectra of none- and bio-conjugated CdSe/ZnS and CdSeTe/ZnS quantum dots (QDs) have been studied. QDs, characterized by emission at 605, 655 and 705nm, have been conjugated with anti Interleukin 10 [...]

Aerosol based fabrication of thiol-capped gold nanoparticles and their application for gene transfection

Byeon J.H., Roberts J.T., Purdue University, US

Thiol-capped Au nanoparticles can be used as sensitive probes of gas and vapor concentrations, as magnetic materials in data storage devices, for selective drug delivery, and for biomedical imaging.3 In this study, ambient-spark-produced-Au-nanoparticle-laden nitrogen gas [...]

Fabrication of Microelectrodes on Polyester Membranes for Dielectrophoretic Cell Capture

Hanke C., Dittrich P.S., Reyes D.R., National Institute of Standards and Technology, US

We present a new system for cell capturing on porous polyester (PET) membranes using dielectrophoretic forces. For the first time gold microelectrodes were fabricated on PET membranes using conventional photolithographic techniques. Their characterization revealed no [...]

Mechanical Characterization of Prion Fibrils using Coarse-grained Modeling Approach in Silico

Yoon G., Kim Y.K., Eom K., Na S., Korea university, KR

Recently, prion is aroused interest with amyloid for its fatality in human and animal`s disease such as Creutzfeldt–Jakob disease and bovine spongiform encephalopathy. The prion has nanoscale long fibrillar form and exists high mechanical properties, [...]

Bicelles: New Lipid Nanosystems for Biomedical Applications

Barbosa-Barros L., Rodriguez G., Rubio L., Cocera M., Alonso C., de la Maza A., Lopez O., Inst. Advan. Chemistry Catalonia-CSIC, ES

Bicellar nanosystems are a fascinating category of morphologically adaptable and versatile lipid assemblies consisting in bilayered disk-shaped nanoaggregates formed in water by long and short alkyl chain phospholipids. Characteristics of these bicellar systems, such as [...]

Nanoscale SPM Characterisation of Nacre Argonite Plates and Synthetic Human Amyloid Fibres

Grishin I., Tinker C., Allsop D., Robson A., Kolosov O.V., Lancaster University, UK

Nacre exhibits structural robustness despite the brittle nature of its constituents. A detailed understanding of its fabrication principles developed in nature can lead to new ideas in material design and synthesis. But due to this [...]

Novel smart bio-nanomaterials: bioactive glasses containing metal nano-particles conjugated with molecules of biological interests

Malavasi G., Lusvardi G., Menabue L., Ferrari E., Saladini M., Aina V., Martra G., Bergandi L., Ghigo D., University of Modena and Reggio Emilia, IT

Stimuli-responsive materials (smart materials) hold great promises for social and economic development and are of great relevance in both fundamental research and technological applications. Their design and realization through innovative processes involve complementary expertises, with [...]

Hyaluronan-modified Magnetic Hydroxyapatite Nanoparticles for Hyperthermia

Wu H.C., Hsieh S.-Y., Wang T.-W., Tatung University, TW

The success of tumor therapy is determined by the efficiency with which the killing of tumor cells is achieved under conditions of no or only slight damage to the normal tissues. Because of its high [...]

Novel Organofunctional Silane Coatings on Silica-Coated Ti

Matinlinna J.P., Tsoi J.K.H., The University of Hong Kong, HK

This in vitro study characterizes a developed novel silane system method to produce coatings on Ti. Hydrophobic coatings are needed in prosthetic dentistry to promote durable adhesion between luting resin cements and coated Ti surfaces. [...]

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