Novel smart bio-nanomaterials: bioactive glasses containing metal nano-particles conjugated with molecules of biological interests

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Stimuli-responsive materials (smart materials) hold great promises for social and economic development and are of great relevance in both fundamental research and technological applications. Their design and realization through innovative processes involve complementary expertises, with comparable efforts on both synthetic and analytical sides. Within this work new smart materials based on phospho-silicate bioactive sol-gel glasses are been developed. To meet the ever-increasing demands for performing bio-materials, the surface features are been tailored to achieve optimal behavior in different applications (drug delivery, enzymes activity, chemo signalling probe, stimuli-sensitive agents). The introduction onto the glass surface of metal nanoparticles (Au and Cu NPs) are very useful because the NPs can directly act as bactericides and imaging agents and can be used to immobilize an enzyme/protein and/or a drug on the glass surface through the formation of self-assembled monolayers, in order to obtain a stable bio-conjugate systems. The materials prototyped in this way could be useful as a material bio-implantable into the human body. In this contribution we reported the development of smart bio-nano-materials. In the present contribution we have prepared and characterized bioactive glasses continuing CuNPs in order to prepare an antibacterial biomaterials useful in the filed implantation surgery.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: June 18, 2012
Pages: 114 - 117
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Biomaterials
ISBN: 978-1-4665-6276-9