Bio Nano Materials – TechConnect Briefs

DNA/RNA Purified Single Walled Carbon Nanotubes on Self-Assembled Networks

Jeynes J.C.G., Mendoza E., Chow D., McFadden J., Silva S.R.P, University of Surrey, UK

Carbon Nanotubes (CNT) have attracted a huge interest in the research community to their extraordinary properties. However, the production methods, specially in the case of single walled CNT (SWNCT), also create a high number of [...]

pH-Sensitive Nano-Crystals of Carbonate Apatite Regulate Delivery and Release Kinetics of DNA for Efficient Expression in Mammalian Cells

Chowdhury E.H., Akaike T., Tokyo Institute of Technology, JP

The completion of whole human genome sequencing encourages the development of a powerful gene delivery technology for elucidating structure, regulation and function of genes and proteins in addition to the emerging biomedical applications, such as [...]

Multivalent Circular Aptamers: Versatile Nanostructures for Biomedical Applications

King G.C., Knox S.M., Williams B.B., Harris J., Gupta D.M., Di Giusto D.A., Gabutero E.R., Tyrelle G.D., Lai Y.-C., Aung M.T., McCutcheon S.T., Voelcker N., Le H.T.T., School of Biotechnology and Biomolecular Sciences, AU

Much recent interest has focussed on applications of DNA in nanotechnology, while chemical biologists have adapted evolutionary processes to generate aptamers, folded nucleic acids with molecular recognition properties similar to protein antibodies. As yet there [...]

Nanofabrication of Bioselective Materials using Diverse Nanolandscapes Displayed on Live Viruses

Petrenko V.A., Olsen E.V., Sykora J.C., Kouzmitcheva G.A., Sorokulova I.B., Brigati J.R., Chen I-H., Chin B.A., Vodyanoy V.J., Auburn University, US

Filamentous phage, such as fd used in this study, are thread-shaped bacterial viruses. Their outer coat is a tube formed by thousands equal copies of the major coat protein pVIII (Figure 1, left). We constructed [...]

Bioactive Ferrimagnetic Glass-Ceramics for Magnetic Induction Hyperthermia

Bretcanu O., Vernè E., University "Politecnico di Torino", IT

Ferrimagnetic glass-ceramics are potential candidates for magnetic induction hyperthermia, which is one form of inducing deep-regional hyperthermia, by using a magnetic field. The aim of this work is the preparation and characterization of innovative bioactive [...]

Calcium-Alginate Nanoparticles for Nonviral Gene Delivery

You J-O, Peng C-A, University of Southern California, US

Natural biopolymers are widely used in the filed of drug and gene delivery. In this study, alginate nanoparticles were prepared using water-in-oil microemulsion as a template followed by calcium crosslinking of guluronic acid units of [...]

Toxicity of Nanomaterials to Living Cells

Jin Y., Wu M., Zhao X., University of North Dakota, US

We have investigated the toxicity of nanomaterials to living cells at the cellular and molecular levels. Recently, nanomaterials have being rapidly developed and shown great potential for use in various bioapplications due to their unique [...]

Colloidal ß-TCP Facilitates Synthesis of Collagen Nano-composite

Shibata Y., Yamamoto H., Miyazaki T., Showa University, JP

Recently, hydroxyapatite/collagen composites have received much attention in the field of tissue reconstruction, because human bone is mainly composed of hydroxyapatite and collagen fibers. However, these composites cannot be synthesized without secondary treatments, therefore the [...]

Amelogenin Nanospheres Supra-Molecular Assembly and the Preferential Orientation of Apatite Crystals

Moradian-Oldak J., Du C., Falini G., University of Southern California, US

Amelogenin self-assembly into nanospheres has been recognized as a key factor in controlling the oriented and elongated growth of carbonated apatite crystals during tooth enamel formation. We investigated the process of amelogenin self-assembly into higher [...]

Ca-Mg Phosphate Nano-Crystals for High Efficiency Gene Delivery and Expression in Mammalian Cells

Chowdhury E.H., Akaike T., Tokyo Institute of Technology, JP

Significant efforts are now being made for the development of non-viral gene-delivery techniques as alternatives to the viral vectors for basic research and clinical medicine. Despite existence of a wide variety of non-viral techniques particularly [...]

Nanotechnology Based on Spatially Fixed ds DNA (RNA) Molecules

Zakharov M.A., Yevdokimov Yu.M., Skuridin S.G., Nechipurenko Yu.D., Engelhardt Institute of Molecular Biology of RAS, RU

A new strategy of creating nucleic acid nanostructures is described. Our approach is based not on isotropic dsDNA (or RNA) molecules, but on these molecules fixed in spatial structure of their liquid-crystalline particles.The nanostructure formed [...]

Development of Nano-sized Protein Arrays using Block Copolymer Self-Assemblies

Jung H-T, Jung J-M, Kwon K.Y., Ha T-H, Chung B.H., Jung H-T, Jung J-M, Korea Advanced Institute of Science and Technology, KR

The single molecule approach is potentially of great technological interest as a complementary means to obtain information about protein conformation or molecular interaction. The measurement for molecular interaction in single molecule level requires that the [...]

Regular Nano-Pores Fabricated By UV Cross-Linking Non-softbaked SU-8 Resist In a Solvent Evaporation Controlled Environment

Chang C-J, Tseng F-G, Yang C-S, National Tsing Hua University, TW

This paper proposes a novel technology to fabricate 3D nano pore structures in SU-8 resist, a widely employed resist in MEMS and Bio-chips. Controlling the evaporation rate in SU-8 fabrication process, regular porous structures with [...]

Magnetic Nanoparticles for Self Controlled Hyperthermia Treatment of Tumors

Haik Y., Mohite V., Chen C-J., Center for Nanomagnetics and Biotechnology, US

Self controlled magnetic hyperthermia at tumor sites requires magnetic particles with Curie temperature similar to that of the desired tumor temperature. Elevated temperature at the tumor site was reported to decrease the tumor resistivety to [...]

Guided Neurite Growth on Patterned Carbon Nanotubes

Zhang X., Prasad S., Niyogi S., Ozkan C.S., Ozkan M., Ozkan C.S., Ozkan M., University of California Riverside, US

Nanomaterials substrates are suitable for functioning as cell scaffolds. Promotion of axonal growth and support for long distance regeneration are the two requirements in the various experimental strategies for spinal cord repair. Organic systems’ performance [...]

Ferromagnetic Microdisks: Novel Magnetic Particles for Biomedical Applications

Novosad V., Fradin F., Buchanan K.S., Guslienko K.Yu., Yefremenko V., Rosengart A.J., Guy S.G., Bader S.D., Argonne National Laboratories, US

Biomagnetic technologies rely on the ability of biological substances to form supra-molecular structures when they are mixed with magnetic nanoparticles. In this report we will demonstrate how thin film growth technique combined with traditional mask-transfer [...]

Hierarchical Natural Materials: Nanostructured Keratin

Martínez-Hernández A.L., Velasco-Santos C., de Icaza M., Martínez-Hernández A.L., Santiago-Valtierra A.L., Castaño V.M., CFATA-UNAM /ITQ, MX

Smart materials are required in devices in order to develop different functions referent to control and automation. The performance and applications of these materials have been growing in the last years and recently their development [...]

IBAD Nanothick Bioceramic Incorporation on Metallic Implants for Bone Healing Enhancement. From Physico/Chemical Characterization to In-vivo Performance Evaluation

Coelho P.G., Lemons J.E., University of Alabama at Birmingham, US

Preliminary data on in-vivo performance of nanothick bioceramic IBAD-coated metallic implants showed an increase in both osteoblastic activity and mechanical properties for bone surrounding these implants. The purpose of this study was to characterize a [...]

Phosphorylcholine-protected Nanoparticles Functionalized with Both Magnetic and Photoluminescent Properties

Chung Y-C, Chen C-J., National University of Kaohsiung, TW

We prepared the magnetite core coated with nano-graded ZnS shell to display superparamagnetic and photoluminescent properties. By adsorbing the phosphorylcholine-ended thiol to stabilize the core-shell nanoparticles, the particles can be well-dispersed in aqueous buffer solution [...]

Hetero-bifunctional Poly(ethylene glycol) Modified Gold Nanoparticles as an Intracellular Tracking and Delivery Agent

Fu W., Shenoy D., Li J., Crasto C., Jones G., Dimarzio C., Sridhar S., Amiji M., Northeastern University, US

To increase the targeting potential, circulation time, and the flexibility of surface-attached biomedically-relevant ligands on gold nanoparticles, hetero-bifunctional poly(ethylene glycol) (PEG, MW 1,500) was synthesized having a thiol group on one terminus and a reactive [...]

Superparamagnetic Iron Oxide-Gold Core-Shell Nanoparticles for Biomedical Applications

Saini G., Shenoy D., Nagesha D.K., Kautz R., Sridhar S., Amiji M., Northeastern University, US

Iron oxide nanoparticles (NPs) in the form of maghemite and magnetite have been used for targeted drug delivery, magnetic cell sorting, magnetic resonance imaging (MRI) contrast agents and immunoassays. Surface modification of these NPs is [...]

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