Preliminary data on in-vivo performance of nanothick bioceramic IBAD-coated metallic implants showed an increase in both osteoblastic activity and mechanical properties for bone surrounding these implants. The purpose of this study was to characterize a thin-film bioceramic coating obtained by Ion Beam Assisted Deposition (IBAD) on Ti-6Al-4V implants and evaluate its in-vivo performance in an animal model. Control (C) and IBAD-coated implants were analyzed through SEM, EDS, ion-milling + XPS for depth profiling, and thin-film XRD. 60 cylindrical implants were bilaterally placed in the tibias of 6 beagle dogs through sequenced surgical procedures and were biomechanically tested (torque) at 3 and 5 weeks in-vivo. No thin-film was detected by SEM, and the EDS Spectra for IBAD coated implants showed Ca presence. XPS showed Ca, P, Si, C, and O at outer layers with variable Ca/P ratios as a function of depth. XRD spectra revealed an amorphous microstructure for IBAD implants. Biomechanical tests showed that IBAD-coated implants had superior fixation competence compared to control implants at 3 and 5 weeks in-vivo. According to the results, it was concluded that the nanothick surface coating enhanced the biological response of bone to implant, supporting opportunities for increased bone healing response in clinical practice.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Pages: 316 - 319
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech