Papers – Page 23 – TechConnect Briefs

3D Molecular Theory of Solvation Coupled with MD for Nanomedical Sciences

Kovalenko A., National Institute for Nanotechnology, CA

We have coupled the statistical-mechanical, molecular theory of solvation (a.k.a. 3D-RISM-KH) with molecular dynamics (MD) simulation in the Amber molecular dynamics package to contract solvent degrees of freedom. This included a number of accelerating schemes [...]

3D-RISM-KH approach for biomolecular modeling at nanoscale: Thermodynamics of fibril formation and beyond

Blinov N., Dorosh L., Wishart D., Kovalenko A., University of Alberta/National Institute for Nanotechnology, CA

As an alternative to the conventional solvation models, we propose to use the three-dimensional molecular theory of solvation (3D-RISM-KH approach) as an essential part of a multiscale approach for nanomedical applications. Based on the rigorous [...]

Plasmonic Nanobubbles: tunable and transient probes for cancer diagnosis, therapy and theranostics

Lukianova-Hleb E., Drezek R., Hafner J., Lapotko D., Rice University, US

We report a tunable theranostic probe that can support the diagnosis, therapy and therapy guidance in one process in individual cancer cells. This probe is a plasmonic nanobubble (PNB), which is not a particle but [...]

Multi-Modal Superparamagnetic Nanoprobe: Harnessing Magnetic, Nuclear, and Optical Power for Diagnostic Imaging Applications

Bumb A., Regino C.A.S., Bernardo M., Dobson P.J., Choyke P., Brechbiel M.W., National Cancer Institute, US

Accurate characterization of the first draining sentinel lymph nodes in primary tumors is a challenging task where current methods rely on nodal size as the primary yardstick for differentiating benign from malignant nodes. Other parameters [...]

Qdot® nanocrystals in intracellular flow: ZAP-70, KI-67 and five-colors fluorophores panel

Sotnikov I., Jaron S., Konopleva M., O’Brien S., Andreeff M., Hildebrant J., Manis J., Brown J., Vorobjev I., Barteneva N., Immune Disease Institute, Harvard Medical School, US

We present, for the first time, the methodological approach for the measurement of cytoplasmic Zap-70 and nuclear Ki-67 proteins with Qdot® nanocrystals-labeled antibodies. Mononuclear cells from chronic lymphoid leukemia patients were used to detect Zap-70, [...]

Nanomaterials Employed in Effective Tumor Treatment

Liang X-J., National Center for Nanoscience and Technology of China, CN

Chemotherapy is one of most effective cures to treat different of malignant tumors. Cisplatin is a chemotherapeutic compound commonly used in clinics, however, acquired resistance confines its application in chemotherapeutics. To overcome the acquired resistance [...]

Development of new thermo-ablation therapy using magnetic nanoparticles and device for alternating magnetic field

Hashimoto S., Oda T., Yamada K., Ohara Y., Ohkohchi N., Kanamori T., Ikehata Y., Nagano I., Yanagihara H., Kishimoto M., Kita E., University of Tsukuba, JP

Although induction heating cancer therapy (IHCT) using magnetic nanoparticles can be a promising approach to treatment-less multi-nodular cancers, combination of conventional super paramagnetic particle (SPIO) and standard alternating magnetic field (AMF) generator confer insufficient heat [...]

Zebrafish as a universal in vivo model for plasmonic nanoparticle medicine

Lukianova-Hleb E., Santiago C., Wagner D., Hafner J., Lapotko D., Rice University, US

In vivo application of plasmonic methods faces serious challenges because standard animal models are not well suited for optical activation and detection of plasmonic effects and for precise control the distribution and interactions of the [...]

Multimodality therapy: Enhancement of melanoma cell death with combination of heat shock protein 90 inhibitor, 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), and gold nanoparticles in a noninvasive radiofrequency field

Kaluarachchi W.D., Curley S.A., M.D. Anderson Cancer Center, US

Melanoma is the most deadly form of skin cancer. Hyperthermia has been used to treat advanced stage melanoma. However, solid tumors often respond minimally to hyperthermic treatment due to the thermo-tolerance induced by chaperons of [...]

Multifunctional Fe3O4/ZnO core-shell nanoparticles for photodynamic therapy

Beltran J.C., Tomar M.S., Singh S.P., Perales O., Rivera L., Peña S., University of Puerto Rico-Mayagüez, PR

The photodynamic therapy (PDT) based on core-shell structures require efficient luminescence within specific wavelength range, preferably in near infrared. In the present study we aim to create a multifunctional platform for PDT through Fe3O4/ZnO core [...]