Papers – Page 59 – TechConnect Briefs

Nanobiodevices Integrating Biomolecular Motors

Ramachandran S., Wu D., Nitta T., Tucker R., Phillips A., Hess H., University of Washington, US

Biomolecular motors, such as the motor protein kinesin, can serve as force-generating modules in hybrid nanodevices. We will present recent progress in utilizing these motors for nanoscale transport of target reagents and discuss applications, such [...]

Surface Modification Chemistries and their Utilization in Microarrays, Diagnostics and Drug Delivery

Lodhi M.A., Opperman G.W., Wall J.V., Anderson A.B., SurModics, Inc., US

Availability of DNA sequence data on numerous organisms has revolutionized the way biological queries are addressed today. Focus of activity has largely shifted from discovery to application. Things that were considered far-fetched only a few [...]

Design and Applications of a Novel Type of Hairpin Probes: Addressable Bipartite Molecular Hook (ABMH)

Landré J.B.P., Ruryk A., Schlicksbier T., Russwurm S., Deigner H.-P., University of East Anglia, UK

ABMHs but not TMBs display the characteristic melt curves obtained with MBs. Moreover, ABMHs specificity in solution (Figure 2) is similar to those of MBs (i.e. differentiation between a perfect match and a 1 mismatch [...]

A Demonstration of High-throughput Immunoassay and Small Molecule Binding on Protein Microarrays with SPR Microscopy

Kim G., Jiang L., Rathod P.K., Campbell C.T., Nishimoto A., Casasanta V., University of Washington, US

The use of Surface Plasmon Resonance (SPR) for the detection of biomolecular binding events at the nanometer scale is of great utility when expanded into microarray density formats. Protein microarray analysis is particularly well suited [...]

Apoptosis of the Human Neutrophils under a Lipopolisaccharide (LPS) of Proteus Mirabilis Condition Observed in Real Time by Atomic Force Microscopy (AFM)

Pleskova S.N., Guschina Yu., Zvonkova M.B., Medical State Academy Nizhniy Novgorod, RU

The goal of present work was to receive the images of apoptosis process in dynamics after addition of Proteus mirabilis 210 LPS and to measure the mechanical properties change of neutrophils’ membranes. We observed the [...]

New Ferrocene-Functionalized Cationic Polythiophene For Label-Free Electrochemical DNA Detection

Harding-Lepage P., Le Floch F., Leclerc M., Ho H.-A., Harding-Lepage P., Leclerc M., Université Laval, CA

A specific polycationic polythiophene was discovered in order to identify dsDNA from ssDNA. The main properties of this new polymer are its conformational possibilities associated with photophysics modifications. This conjugated polymer is still subject to [...]

Cationic Polythiophene for Label-Free, Colorimetric and Fluorometric Detection of DNA

Ho H.-A., Leclerc M., Université Laval, CA

In order to respond to new demands and needs in modern medical diagnostics and biomedical research applications, a lot of new DNA detection approaches have been reported. However, most of these methods have the disadvantage [...]

Boolean Networks (BN) Based Molecular Biology Modeling: Protein Process

Yeol J.W., Barjis I., Barjis J., Barjis I., Barjis J., Berri S., Ryu Y., Polytechnic University, US

In this paper, we introduce a new application of modeling tool; Boolean Networks (BN). In particular, it shows how, by means of a Boolean Networks (BN), the protein production process can be modeled and analyzed. [...]

Imaging Ellipsometry: A Powerful Method for Biochip Development, QC and Evaluation

Laging M., Hoenig D., Eing A., Accurion, US

Biochip applications nowadays are taking the step from DNA to protein applications. Proteins show a vasting variety concerning their individual chemical behaviour, demanding new techniques regarding chip substrates and immobilization chemistries. Furthermore the use fluorescent [...]

Binding Efficiency Improvement of Antibody to Antigen on Mixed Self-Assembly Monolayers

Wu C-L, Lin Y-W, Hsu Y-L, Tseng F-G, Chieng C-C, National Tsing Hua University, TW

We make a mixed Self Assembly Monolayer for improve binding efficiency antibody, this method provide s stereo advantage and didn't need to modify antibody by moelcuar biology ono by one.