Diagnostics & Bioimaging – Page 21

Label-free, Fluorescenece Detection of DNA Nanoparticle Scaffolds

Kell A.J., Tan S., Charlebois I., Boissinot M., Simard B., National Research Council, CA

We have developed a nanoparticle-based DNA biosensor that can detect unlabelled ssDNA with good sensitivity (picomolar concentrations). The biosensor makes use of the optical changes of a cationic polymer interacting with ssDNA versus that of [...]

Bio Sensors, Diagnostics & Imaging

Magnetic Nano Particles for Diagnostics

Nguyen K.C., Pham V.H., Do S.T., Tieu D.T., SAIGON HI TECH PARK, VN

Magnetic Nano Particles (MNP) for diagnostics had been fabricated by coating the particle ‘s surface with specific coupling agents . This agent allows the pulling the virus containing DNA and/or RNA molecules off the patient [...]

SERS Gold Nanoparticles for Cancer Surface Marker Detection

Nguyen C.T., Nguyen J., Nguyen C.T., Nguyen J., Rutledge S., Wang C., Walker G.C., University of Toronto, CA

Surface Enhanced Raman Scattering (SERS) gold nanoparticles may provide novel optical tags for cellular analysis. Currently, cell markers are mostly assessed by fluorescence labeling using flow cytometry. However, fluorescence dyes are usually limited to 4-5 [...]

Photothermal Characteristics study of PEGylated Gold Nanorods

Shih T-Y, Lin J-T., Tien C.C., Tseng P-L, Chen Y-H, Industrial Technology Research Institute, TW

Gold nanorods have a growing role in a diversity of medical applications especially in the area of hyperthermal therapy of tumor. Since localized temperature rising by laser irritation gold nanorods at near-IR frequency can induce [...]

Fluorescence Based Specific PNA-DNA Binding Characterization on nano-FET DNA Device Surface

Rastogi S.K., Mishra N.N., Finaloski B., Cameron E., Maki W., Postdoc Researcher, US

A novel sequence of peptide nucleic acid (PNA; beta-Ala-(T10)-beta-Ala-NH2) containing ten thymine monomers and beta-alanine amino acid at both (C and N) terminal of main chain was synthesized manually using solid phase tBoc peptide chemistry. [...]

Monitoring of the major blood vessels supplying head and brain (carotid arteries) contactlessly

Kaminska B., Simon Fraser University, CA

An apparatus for measuring Carotid Arteries movement without physically connecting electrodes or other sensors to the body was developed. The measurement system was implemented to simultaneously monitor the Carotid Arteries and ECG in order to [...]

Relaxation Time Constants of Nanometals in Human Tissues and Clinical Applications

Sharma A., Sharma R., Sharma A., Sharma R., Center of Nanotechnology, IN

The metals are in abundance in human body in biofluids, blood, cerebrospinal fluid, saliva, lymph. These metals are found in free and bound forms in each tissue and their amount is tissue specific. The mechanism [...]

Extended Applications of Picomolar Technology to Measure Immunoactive Biomarkers

Shriniwas B.D., Sharma A., Sharma R., Sharma A., Sharma R., RTM Nagpur University, IN

The picotechnology extended use in marine and biology applications are reported after our report on picotechnology to measure picomolar quantities of single stranded DNA in evaluation of Texotere chemosensitivity (TCRT,2008,28(6):175). Lead and mercury poisoning is [...]

Label-free direct detection of analytes from optically inaccessible samples

Brousseau L.C., Quantum Logic Devices, US

Fluorescent optical methods for biomolecular detection are widely used for research and diagnostic applications. However, these techniques are useful only in sample matrices that are optically transparent non-scattering, which precludes most biologically relevant fluids, such [...]