Diagnostics & Bioimaging – Page 18

On-Chip Ion-selective Microesensor for Evaluation of Mitochondrial Membrane Potential

Lim T.-S., Dávila A., Wallace D.C., Burke P., UC Irvine, US

The mitochondrial membrane potential is used to generate and regulate energy in living systems, driving the conversion of ADP to ATP, and controlling apoptosis, all central to human health and disease. Therefore, there is a [...]

Development and practical application of biosensors based on the nanostructured silicon

Starodub N., Mel’nichenko N., Shmireva A., Shuljak L.N., National University of Life and Environmental Sciences of Ukraine, UA

In this report the principle new instrumental method of the biochemical diagnostics of the bovine leucosis, autoimmune process at the diabetes and the control mycotoxins through the registration of the formation of the specific immune [...]

Electrochemiluminescent sensor for clinical analysis based on Carbon Nanotube electrodes

Sanginario A., Demarchi D., Giorcelli M., Castellino M., Politecnico di Torino, IT

Presented application is based on the use of carbon nanotubes (CNTs) for biomolecular analysis using electrochemiluminescence (ECL) detection technique. For this purpose we have grown self standing cylinder-shaped blocks of Multi wall CNTs (MWCNTs) by [...]

Non-labeled DNA Biosensor Post-Processing Signals Analyses

Afuwape S.A., National University, US

The evolution of DNA biosensors should match commercial emergency of Nanotechnology in this genomic era. The ubiquitous oligonucleotide microarray ‘lab–on-chip’ is limited by high cost and man-power. However, emerging portable non-label DNA biosensors are yet [...]

Phosphate recognition using multilayer charged thin films containing zirconium (Zr) ions for biochip applications

Lee M., Kim J.H., Kim N., Kim S-H, Kim J.H., Kim N., Kim S-H, Shin C.-J., Koh K., Kim J.H., Kim N., Kim S-H, Ajou University, KR

The phosphate residue plays an important role as not only the structural component of DNA and lipid but also the activation signal of protein in the cellular signaling pathways. Therefore, the selective recognition for the [...]

Nanospring™ Enhanced Enzyme-linked Immunosorbent Assay for Increased Sensitivity and Early Detection

Beaux M.F., Cantrell T., Prakash T., Corti G., McIlroy D.N., Norton M.G., GoNano Technologies, Inc., US

GoNano Technologies NanospringTM material is proposed as an enhancement of enzyme-linked immunosorbent assay (ELISA) to increase detection sensitivity. The high surface area and hydroxyl rich surface chemistry provides greater attachment capability and decreased functional surface [...]

Fabrication of plastic optical label-free biosensor and Immunodetection of cardiac marker in human serum

Kim B-K., Kim K.H., Hong J.C., Ko H.S., Kim B-K., Kim K.H., Huh C., Sung G.Y., ETRI, KR

We have studied for lab-on-a-chip (LOC) based bio-devices and fabricated plastic optical label-free biosensor device. Optical resonant reflection biosensor (ORRB) is a kind of label-free sensor, containing nanoscale resonate grating patterns1 and whole blood filter. [...]

Functionalized Nanopipette: towards single cell immunoassay

Actis P., Jejelowo O., Pourmand N., UC Santa Cruz, US

Nanopipette technology is capable of detecting and functional analyzing bio-molecules based on difference on their size, shape and electrical charge. This unique label-free biosensor is inexpensive, easy to fabricate and versatile. Nanopipette functionalized with antibodies [...]

Solid-state nanopores: a new tool for biomedical diagnostics

Khongkow M., Instuli E., Ivanov A., Albrecht T., Edel J.B., Imperial College London, UK

In this work, we present first results from the experimental implementation of an electrode/nanopore architecture with the aim of characterizing ion and DNA transport under the influence of a local alternating electric field. This includes [...]

Synchrotron radiation microtomography for the ex-vivo and in-vivo evaluation of nanoparticle-labeled stem cell homing in muscular tissue

Fiori F., Farini A., Giuliani A., Manescu A., Villa C., Torrente Y., Polytechnic University of Marche, IT

This work was carried out in the frame of a more general research program aiming to use human stem cells to repair muscle damage in Duchenne Muscular Dystrophy. The results of X-ray microtomography experiments, carried [...]