Topic: Biomaterials
Spatio-temporal Tumor Model for Analysis and Mechanism of action of Intracellular Drug Accumulation
We have developed a one-dimensional tumor simulator to describe the biodistribution of chemotherapeutic drugs to a tumoral lesion and the tumor cell’s response to therapy. A three-compartment model is used for drug dynamics within the [...]
Upconverting nanoparticles for photodynamic therapy
Photodynamic therapy involves killing of diseased cells by excitation of photosensitizer chemicals with high energy light to produce cytotoxic oxygen species from surrounding dissolved oxygen. However, poor tissue penetration of high energy light and hydrophobic [...]
Pharmacokinetic study of PEGylated plasmon resonant gold nanoparticles in tumor-bearing mice
Kogan B.Ya., Andronova N.V., Khlebtsov B.N., Khlebtsov N.G., Khlebtsov B.N., Khlebtsov N.G., Rudoy V.M., Dement’eva O.V., Sedykh E.M., Bannykh L.N., FGUP “GNC “NIOPIK”, RU
Gold nanorods and gold nanoshells have been synthesized. Nanorods have length of 50 nm, diameter of 15-20 nm. Nanoshells have 80 nm silica core diameter with 25 nm thick gold shells. Then poly(ethylene glycol) molecules [...]
Multi- Walled Carbon Nanotubes Increase the Efficiency of Hyperthermic Chemotherapy
Levi-Polyachenko N.H., Merkel E., Jones B.T., Wagner W.D., Carroll D.L., Stewart IV J.H., Wake Forest University Health Sciences, US
A clinically applied method to enhance drug localization for abdominal malignancies of colorectal cancer involves a two-hour perfusion of hyperthermic (40-42ºC) chemotherapeutic agents; however, all cavity tissues are subjected to enhanced drug delivery due to [...]
Preparation and investigation of biological activity of thermosensitive liposomes loaded with doxorubicin
Tazina E.V., Polozkova A.V., Orlova O.L., Ignatieva E.V., Mescherikova V.V., Wainson A., Yarmonenko S.P., Oborotova N.A., N.N.Blokhin Russian Cancer Research Center of RAMS, RU
Purpose: Preparation of thermoliposomes with doxorubicin and investigation of their effect on solid Ehrlich carcinoma and B-16 mouse melanoma in combination with hyperthermia. Materials and methods: Thermosensitive liposomes were prepared using DPPC, DSPC, DSPE-PEG 2000 [...]
Multifunctional siRNA Delivery System for Cancer Therapy
The main obstacle to siRNA therapy is in delivering RNA across the cell membrane. Furthermore, new methods for monitoring therapeutic responses are highly desirable. Here we report the development of a multifunctional nanomedicine platform for [...]
Mathematical Model of effect of drug delivery on blood flow in external magnetic field by Magnetic Nanoparticles
Magnetism is one of the major contributors in biological and biomedical research. Efficient drug targeting is vital for the medical treatment of various diseases. In magnetically targeted therapy, a cytotoxic drug is attached to a [...]
Influence of liposome size on accumulation in tumor and therapeutic efficiency of liposomal near-IR photosensitizer for PDT based on aluminum hydroxide tetra-3-phenylthiophthalocyanine
Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Pevgov V.G., Lukyanets E.A., Oborotova N.A., Gurevich D.G., Zorin A.A., Derkacheva V.M., Smirnova Z.S., Loschenov V.B., Vorozhtsov G.N., Baryshnikov A.Yu., A.M. Prokhorov General Physics Institute of RAS, RU
Size of nanoparticles is considered to be the one of main factors determining the efficiency of nanostructural antitumor drugs. Current work was performed to estimate the influence of liposomal size distribution on level and selectivity [...]