Biomaterials – Page 57 – TechConnect Briefs

Counting and Sizing of Virus and Protein Aggregates by Nanoparticle Tracking Analysis (NTA)

Griffiths D., Hole P., Smith J., Malloy A., Carr B., NanoSight, US

A new analytical system is described which provides total particle count and high-resolution size measurements for biological structures such as virus and protein aggregates. This system builds on the Nanoparticle Tracking and Analysis (NTA) technique [...]

Nanoparticle size and shape evaluation using the TSOM optical microscopy method

Attota R., Silver R.M., Vladar A., NIST, US

We present a novel optical technique that produces nanometer dimensional measurement sensitivity using a conventional optical microscope, by analyzing through-focus scanning optical microscope (TSOM - pronounced as ‘tee-som’) images obtained at different focus positions. In [...]

A flow-assisted point-of-care testing device based on gravitational field-flow fractionation for analysis on biological fluids

Mirasoli M., Cevenini L., Casolari S., Roda A., Roda B., Di Carlo A., Reschiglian P., Roda A., Roda B., University of Bologna, IT

The “Point-Of-Care Testing” (POCT) approach is based on the development of portable analytical platforms suitable to perform analysis directly in any required place. A POCT device should combine portability, minimum sample pre-treatment, and the possibility [...]

Bio Analytical Instrumentation

Surface Constructions of Nano-Micro Structured CaP Biomaterials and Their Biocompatibility

Lin C.J., Wang H., Hu R., Lai Y.K., Geng Z.W., Xiamen University, CN

In this work, we concentrated our attention to develop various methods for surface construction of of calcium phosphate (CaP) and their composite coatings, including octacalcium phosphate (OCP), hydroxyapatite (HAp), micropatterned titanium surface by using electrochemical [...]

In Vivo Real Time Raman Spectroscopy Detection of Carbon Nanotube Kinetics in Lymph, Blood and Tissues

Biris A.S., Galanzha E.I., Li Z., Mahmood M., Xu Y., Dervishi E., Zharov V.P., University of Arkansas at Little Rock, US

The development of novel therapies using unique nanostructures for molecular targeting has become a major area of biological research. Here, we present the first report of the use of carbon nanotubes (CNTs) as high contrast [...]

Immobilization of Enzymes on Functionalized Magnetic Nanoparticles for Efficient Biocatalysis

Wang D.I.C., Wang W., Li Z., Wang D.I.C., Wang W., National University of Singapore, SG

In this paper, iron oxide magnetic nanoparticles were synthesized by co-precipitation method and were functionalized with aldehyde group. Spherical superparamagnetic nanoparticles with diameter of 100 nm were obtained based on the results of field emission [...]

From Micro- to Nano- Patterning: Manipulating the Extracellular Matrix and Directing Cell Organization, Migration & Adhesion

Moten A., Harvard Univeristy/Massachusetts Institute of Technology, US

Cells are inherently sensitive to local mesoscale and microscale patterns of chemistry and topography. Recent research has investigated how surface mechanics might dictate cell behavior, affecting both cell function and differentiation. This study professes that [...]

Effects of Crosslinking Condition on Mechanical and Biological Properties of Biomimetic Fibrous Composite Material for Arterial Medial Equivalent

Madhavan K., Belchenko D., Tan W., University of Colorado at Boulder, US

This study involves the mechanical and biological characterization of crosslinked collagen-based scaffolds for arterial medial-equivalent. These scaffolds are made from a mixture of collagen, chitosan and elastin and crosslinked with genipin. The method of optimization [...]

An Evaluation Criteria of Lower Respiratory Tract Infection Drug Resistant Patients in Need of Alveolar Fibroblasts: Match between Carbon Nanotube Bound Fibroblast Defense and Patient Drug Resistance: NIDHI Criteria

Sharma R., Goel N., Kwon S., Florida State University, US

We report first time a criterion of evaluating the need of choosing alveolar fibroblasts immune to lower respiratory tract infection (LRTI) in LRTI patients who display fatal drug resistance and specific pattern of bacterial infection. [...]