Biomaterials – Page 116 – TechConnect Briefs

Modeling of Dielectrophoresis for Handling Bioparticles in Microdevices

Yao G.F., Flow Science Inc., US

Dielectrophoresis can be used to trap and position bioparticles efficiently and sucessfully in BioMEMS devices. This paper present a computational model to simulate this process. In particular, the model will solve for electric potential distribution, [...]

Characterization of Micropumps for Biomedical Applications

Haik Y., Hendrix J., Kilani M., Galambus P., Chen C-J., Florida State University, US

A novel class of micro pump was developed at the Biomagnetic Engineering Lab at Florida State University. The pump operates by utilizing the viscous effects that are dominant the micro scale and by spinning a [...]

A Generic Sensor for Ultra Low Analyte Concentration Detection

Hedley J., McNeil C.J., Burdess J.S., Harris A.J., Dobson M.G., Suarez G., Berney H., Newcastle University, UK

This paper reports on the development of a MEMS based generic mass sensor system (international patents pending) aimed at quantitative analyte measurement with a sensitivity of the order of 0.01 ng per cm sq. The [...]

An Approach for Fabrication of Polymer-based Bio-analytical Microfluidic Devices

Wang M., Weng K-Y, Huang C-C, Liu W-P, Yao L-Y, Industrial Technology Research Institute, TW

Polymer is well suited as a substrate for bio-application devices due to its high dielectric constant, bio-compatible, low cost and ease of microfabrication. The primary goal is the successful fabrication of microchannels for biochip commonly [...]

Modeling of the Dielectrophoretic Forces Acting upon Biological Cells: A Numerical Comparison between Finite Element/Boundary Element Maxwell Stress Tensor Methods and Dipole Point Approach

Benselama A., Pham P., Canot É., CEA, FR

Maxwell Stress Tensor (MST) method is investigated in this study to quantify the degree of approximation made with the point dipole method in respect to dielectrophoresis (DEP) in microdevices. Latex particles and biological cells immersed [...]

Bio Micro Sensors and Systems

Resolved Particle Simulations of Microsphere/Cell-based Bioanalytic Systems

Pant K., Romanowicz B.F., Sundaram S., CFD Research Corporation, US

Microsphere and cell-based assays are emerging as the platform of choice for rapid quantitation of biomolecular interactions in bioagent detection, clinical diagnosis, drug therapy, etc. [1,2] Traditional assay designs have been driven by expensive trial-and-error [...]

Development of an Advanced Simulation System for the Analysis of Particle Dynamics in LASER based Protein Ion Sources

Hieke A., Ciphergen Biosystems, Inc., US

An advanced multi-physics simulation system henceforth referred to as GEMIOS (Gas and Electromagnetic Ion Optical Simulator) has been implemented which allows the computation of 3D trajectories and energy exchange of ion beams/clouds under the influence [...]

DNA and Estrogen Receptor Interaction Revealed by the Fragment Molecular Orbital Method -Implementation of SCF Convergence-

Watanabe T., Inadomi Y., Tanaka S., Nagashima U., National Institute of Advanced Industrial and Science and Technology, JP

The fragment molecular orbital (FMO) method was applied to evaluate the interaction between estrogen response element (ERE) in DNA and DNA binding domain (DBD) of estrogen receptor (ER). In order to calculate the whole electronic [...]

A Monte Carlo Study of a Model of Globular Protein Nanoparticles

Pagan D.L., Gracheva M.E., Gunton J.D., Lehigh University, US

We explore the metastable fluid-fluid coexistence curve of the modified Lennard-Jones model of globular proteins of ten Wolde and Frenkel [4]. Using grand canonical Monte Carlo simulations along with mixed-field finitesize scaling and histogram rewighting, [...]