Medical & Biotech – Page 61 – TechConnect Briefs

Prostate Cancer-Specific Drug Delivery and Imaging System: Design, Synthesis, and Characterization of Multi-functional AuNPs

Dao K-L, Northeastern University, US

A multifunctional gold nanoparticulate (mfAuNPs) drug delivery system that is specific for prostate cancer therapy will be presented. A synthetic modular approach is established to prepare-a)a prostate specific membrane antigen (PSMA) ligands for targeting the [...]

Polymer-based delivery vehicle for cisplatin

Vieira D.B., Menck C.F.M., Carmona-Ribeiro A.M., University of Sao Paulo, BR

Cisplatin (CisPt) is one of the most widely used agents to treat a variety of tumors, but dose-limiting toxicities or intrinsic and acquired resistance limit its application. We report a unique strategy to deliver cisplatin [...]

Enhanced Cell Electro-permeabilisation Combined with Phototherapy to Target-Killing Cancer Cells by Using Multi Functional Carbon Nanotubes

Lee P-C, National Taiwan University, TW

Carbon nanotubes (CNTs) have been proposed and actively explored as multifunctional innovative carriers for drug delivery. This project presents a new modality for cell electro-permeabilisation based on the use of CNTs and external static electric [...]

Investigating the role of the FOXA1 protein in cancer with Scanning Probe Microscopy

Theodorou I., Imperial College London, UK

The FOXA1 protein has generated considerable interest for its use as a biomarker in breast cancer. In this project, the binding kinetics of FOXA1 with the BRCA1 and FOXC2 are investigated using Scanning Probe Microscopy. [...]

Polymersomes and Imaging: A Quantitative Approach

Joseph A.S., Brown N.J., Battaglia G., University of Sheffield, UK

Nano-sized carriers are widely used as imaging tools. Quantification of the amount of carrier delivered provides useful informations in development and testing stages. This work describes a HPLC method to quantify fluorescent labelled polymersomes. Polymersomes [...]

Plasmonic Nanobubbles as Tunable Theranostic Agents

Lukianova-Hleb E., Constantinou P., Danysh D.S. Wagner B., Drezek R.A., Hafner J.H., Farach-Carson M.C., Carson D.D., Farach-Carson M.C., Lapotko D.O., Rice University, US

Plasmonic nanobubbles (PNB) were developed to support a cell level theranostics as the multi-functional, tunable and selective cellular probes. PNB is a transient and tunable vapor nanobubble that is generated on demand around overheated plasmonic [...]

Label-free Raman Micro-Spectral Imaging of the Microenvironment of PANC-1 Spheroids

Chernenko T., Shah R., Zuser E., Diem M., Amiji M., Northeastern University, US

Spheroids are 3D tumor models, which reflect diverse properties of the growing tumor. Due to its avascular microenvironment, initial tumor growth patterns as well as subsequent tumor-core biochemistry may be studied in depth, from which [...]

New High Conductance DEP Devices for Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect cell free circulating (cfc) DNA nanoparticulate biomarkers, drug delivery nanoparticles and virus directly from blood is a major challenge for nanomedicine. We have now developed unique, simple and practical high [...]

Cancer Nanotechnology

Nanoencapsulated Drug-Carrying System for Photodynamic Antimicrobial Chemotherapy (PACT)

Kalapala G.K.M., Fu P.K.-L., Governors State University, US

Chronic wounds are considered as a pandemic health problem. Approximately 1% to 2% of the population in developing countries has experienced a chronic wound during their lifetime. In the United State States,the expense of treating [...]