Medical & Biotech – Page 50 – TechConnect Briefs

Copper complexes loaded on nanostructured TiO2 materials as citotoxic agents of cancer cells

Lopez T., Guevara P., Gómez E., Instituto Nacional de Neurologia y Neurocirugia, MX

In the present work ammonium tetrachlorocuprate (II) and copper (II) chloride were loaded on nanostructured mesoporous titania for determinate their anticancer properties. Copper-TiO2 materials were prepared using the sol-gel technology. Characterization of Copper complexes and [...]

Mn-Zn Ferrite and Photosensitizer Co-Loaded Cancer Theranostic Agent for Magnetic Resonance Imaging and Photodynamic Therapy

Lai P.S., Lai S.M., Yang M.-D., Tung M.-J., Lai P.S., Lai S.M., National Chung Hsing University, TW

Developing a nanodevice with simultaneous cancer imaging and therapy is one of the promising approaches for cancer treatments. In this report, a multifunctional cancer theranostic system based on magnetic resonance (MR) contrast agent and photosensitizer [...]

Electrospun 5-fluorouracil loaded bovine serum albumin-polyvinylpyrrolidone nanofibers

Illangakoon U.E., Chatterton N.P., Williams G.R., Nazir T., London Metropolitan University, UK

5-FU loaded bovine serum albumin (BSA)/ polyvinylpyrrolidone (PVP) nanofibers prepared using an electrospinning process. The nanofibers were characterised by scanning electron microscopy (SEM) energy - dispersion spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction [...]

VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in glioblastoma multiforme tumor

Grodzik M., Sawosz E., Wierzbicki M., Hotowy A., Prasek M., Jaworski S., Chwalibog A., Warsaw University of Life Sciences, PL

Inhibition of tumor angiogenesis suppresses tumor growth and prevents metastasis, and is a key target in cancer therapy. Novel materials, nanoparticles of carbon allotropes (C60 fullerenes, graphite nanoparticles, multi-walled carbon nanotubes, single-walled carbon nanotubes and [...]

Combined targeted hyperthermia and drug delivery with magnetic nanoparticles

Mitrelias T., Tselepi M., Barnes C., Orel V., Schepotin I., Cavendish NanoTherapeutics, UK

Cancer remains the second leading cause of deaths worldwide and in the U.S. alone every year there are over 1.5 million new diagnoses. Technologies that would allow targeted destruction of tumours by localising the delivery [...]

Polymalic acid-based nanodrugs: Anti-tumor efficacy and host compatibility

Holler E., Ding Hui, Patil R., Portilla J., Inoue S., Gangulum P., McNeil S.E., Patri A., Dobrovolskaia M.A., Black K.L., Ljubimova J.Y., Cedars-Sinai Medical Center, US

A polyanionic drug carriers is presented that penetrates biobarriers and targets molecular cancer markers of human breast and brain cancer. The carrier platform is poly(beta-L-malic acid) (PMLA), which is highly water soluble and biodegradable to [...]

Immunodiagnosis for cervical cancer using antibody-gold nanoparticle conjugate

Tapaneeyakorn S., Thepthai C., Apiwat N., Dharakul T., National Science and Technology Development Agency, TH

Cervical cancer is a leading cause of cancer deaths among women. It is most often caused by persistent infections with high-risk human papillomavirus (HPV). Since current screening programs are either complex or costly to run, [...]

EGF conjugated gold and silver nanoparticles for imaging EGFR over-expressing cells

Lucas L.J., Hewitt K.C., Dalhousie University, CA

Purpose: To create and validate a novel SERS-based nanoprobe for optical imaging of the epidermal growth factor receptor (EGFR). Experimental Design: Gold and silver nanoparticles (Au/AgNPs) were synthesized and coupled to epidermal growth factor (EGF) [...]

A Nanopore Biomimetic Device Quantitatively Detects Early Stage Cancer Cells; a Contour Map Multiple Variable Correlation Method Assesses the Heat of Cancer Cells Released

Chen E.T., Shen J. Thornton Y., Ngatchou C., Duh S-H, Kissinger P.T., Advanced Biomimetic Sensors, Inc., US

Detecting low abundance cancer cell is challenged by the complex instrumentation and time consuming assays. We report a unique cancer cell detection device that is capable of detecting low abundance MDA-MB-231 breast cancer cells based [...]

Sector: Medical & Biotech