Medical & Biotech – Page 14 – TechConnect Briefs

Continuous Production of Polymer Coated Drug Crystals, Particles and Nanoparticles by Hollow Fiber Membrane-based Cooling Crystallization and Anti-solvent Crystallization

Sirkar K., Chen D., Singh D., Jin C., Pfeffer R., New Jersey Institute of Technology, US

Polymeric coating can provide protection for fragile drugs from hydrolysis and degradation. With an appropriate polymer coating, nanoparticles are known to traverse the physiological human mucous barrier. Such coatings are also integral to controlled drug [...]

Nanodelivery of cerebrolysin reduces functionalized Gold Nanoparticles induced Blood-brain barrier disruption, brain edema formation and brain pathology

Sharma A., Sharma H.S., Menon P.K., Muresanu D.F., Lafuente J.V., Nozari A., Patnaik R., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Recently, gold nanoparticles (AuNPs) are used for drug delivery in treating several neurological disorders e.g., Alzheimer’s disease (AD), Parkinson’s disease, Stroke and trauma. In addition, use of AuNPs for diagnostic purposes in various diseases are [...]

Molecular toolkits for engineering of self-navigating drug delivery vehicles

Gillespie J.W., Auburn University, US

Analysis of multi-thousand clone populations of the cancer cell-binding landscape phages and their multi-motif proteins using massively parallel sequencing techniques allowed the discovering of a variety of short motifs serving as elementary binding units during [...]

Alginate/Montmorillonite nancomposites for the delivery of curcumin

Ramadan A.R., Ahmed M., The American University in Cairo, EG

Curcumin is a well-known traditional medicine with anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been studied to investigate its use in clinical and therapeutic applications. However, its low water solubility [...]

Materials for Drug & Gene Delivery

ActiVlayr Nanofiber Technology

Hosie I., Revolution Fibres Ltd, NZ

Revolution Fibres Ltd is New Zealand’s premier advanced materials company and a global leader in nanofibre production. Its mission is to enable companies to produce superior products using Revolution Fibres technology for creating functional electrospun [...]

Mechanical Properties of a composite material made of HAp nanofibers

Alanis J.R., Velazquez R., Rivera E.M., Universidad Autónoma de Querétaro, MX

Biomaterials based on hydroxyapatite (HAp) are often studied due to the favorable answer presented as a substitute of bone tissue. However, the mechanical properties of these materials have not been studied deep enough. Synthesis of [...]

Testing of a 3D printed, nanostructured osteochondral implant for knee repair in a small animal model

Holmes B., Kuo C-Y, Arumugasaamy N., Gandhi N., Rossi C., Fisher J.P., Zhang L., Oetgen M., Nanochon, Children's National Medical Center, US

Osteochondral lesions of the knee are difficult injuries to treat [1, 2]. Despite improvements in the diagnosis of these lesions, optimal treatment remains elusive, likely as a result of the complex interactions between host factors [...]

Biogelx: Designer Gels for Cell Culture

Lopez-Bernardo E., Irvine E., Ulijn R., Lightbody D., Biogelx, US

Biogelx Limited is a biomaterials company that designs tuneable peptide hydrogels, offering artificial tissue environments to cell biologists for a range of cell culture applications. The hydrogels are highly tunable, cell-matched biomaterials, capable of revolutionizing [...]

An ex-vivo and in-vivo performance of a switchable carbon nanotube membrane device for transdermal nicotine delivery

Gulati G.K., Berger L., Jackson Hinds B., University of Washington, US

Purpose: Transdermal nicotine patches and nicotine gums therapy along with psychological counseling support is most widely used therapy for smoking cessation, but has low success rate of 25% for 2 year without relapse. An ideal [...]