Medical & Biotech – Page 107 – TechConnect Briefs

Removing Active Species by Fullerenol in vitro and in vivo

Yin J-J., Lao F., Wamer W-G., Zhao Y., Gao X., Wang P-C, Chen C., Liang X-J., National Center for Nanoscience and Technology of China, CN

We previously demonstrated that gadolinium endohedral metallofullerenol ([Gd@C82(OH)22]n nanoparticles) had high inhibitory activity on growth of malignant tumor in vivo by uncertain mechanism(s). The activities of enzymes associated with the metabolism of reactive oxygen species [...]

Novel Resorbable Drug-Carrying Nano-Scaffolds for Treating Bone Diseases at Targeted Sites

Liu H., Webster T.J., Brown University, US

Pharmaceutical agents are often required to stimulate new bone formation for the treatment of bone injuries or diseases (such as osteoporosis and osteosarcoma). However, there are several problems associated with current drug delivery methods. First, [...]

Carbon Nanopipes dispersions in aqueous solutions and effects on cell viability

Whitby M., Lin J., Quirke N., Thanou M., Imperial College London, UK

The development of carbon nanomaterials for biomedical applications appears highly attractive due to their nanoscale properties although their biological profile is still in doubt. Herewith, we report that the amorphous vs crystalline character of carbon [...]

Multifunctional Polymeric Nanosystems for EGFR Gene Silencing

Pai S., Amiji M., Northeastern University, US

Multifunctional polymeric nanoparticles with an average size of 200nm could be prepared using the solvent displacement technique. Cetyltriethylammonium bromide (CTAB) surface-modified poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticles encapsulated PTX and siRNA with a loading efficiency > [...]

Improved Tissue Distribution, Renal Clearance and Toxicity Profile of Functionalised Carbon Nanotubes

Lacerda L., Prato M., Bianco A., Kostarelos K., The School of Pharmacy, University of London, UK

Carbon nanotube (CNT) development for biomedical applications is in the nascent stages, however is thought to lead to novel types of diagnostic, therapeutic and regenerative nanomedicines. The construction of CNT-based delivery systems able to traffick [...]

NanoBio-Tools for Selective Activation of Toll-like receptors (TLRs)

Shukoor M.I., Natalio F., Langguth P., Schreiber W., Schröder H.C., Müller W.E.G., Tremel W., Johannes-Gutenberg University, DE

One of the emerging goals of nanotechnology is to functionalize inert materials to impart precise biological functions resulting in biocompatible nano-platforms. The exploration of the interaction between nanostructured materials and living systems is of fundamental [...]

Potential anti-inflammatory properties of biologically-synthesized nanoparticles of gold or silver

Vercruysse K.P., Harper S.L., Ivory D.M., Whalen M.M., Saili K.S., Tanguay R.L., Tennessee State University, US

Ionic gold (Au) compounds have been used for many years in the treatment of rheumatoid arthritis (aurotherapy). Despite their long history, the basis for their therapeutic properties has never been established definitively. We have observed [...]

Nanoparticle-enhanced Magnetic Field Induces Apoptosis in Nematode

Huang G.S., Yeh L.K., Chen Y-C, National Chiao Tung University, TW

To investigate molecular consequence of magnetic field to C. elegans, Fe3O4 nanoparticles were incorporated into the culture media of C. elegans and the nematodes were grown under magnetic field for 4 days. For the expermental [...]

Magnetically associated carbon nanotubes with mammalian cells: flow cytometry characterization and applications

Cai D., Blair D., Dufort F.J., Gumina M.R., Huang Z., Hong G., Kempa K., Ren Z.F., Chiles T.C., Boston College, US

Magnetic CNT can be driven into cells because it has an embedded Ni nanoparticle in its tip. We show herein that CNT-cell complexes are formed in the presence of a magnetic field. The complexes were [...]

The different biological activity between the colloidal silver nanoparticle and the plasma silver nanoparticle in various cell types

Kim S-G, Hallym University, KR

Purpose: The objective of this study was to exam any difference after treatment of nanoparticle in cellular proliferation and gene expression in various cell types. Particularly, it was compared between the colloidal silver nanoparticle and [...]