Fujita M., Khazenzon N.M., Lee B-S, Holler E., Black K.L., Ljubimova J.Y.
Cedars-Sinai Medical Center, US
Keywords: angiogenesis, nanoconjugate, tumor markers, tumor-specific drug delivery
Tumor cell-specific drug targeting is the major goal of nanotechnology-based platforms. A nanoconjugate Polycefin was synthesized for targeted delivery of antisense oligonucleotides and antibodies into tumors. The delivery of antisense oligonucleotides to α4 and β1 chains of a vascular basement membrane protein, laminin-8, suppressed its synthesis in vivo. Treatment of glioma-bearing rats significantly diminished tumor vascularity (p
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Pages: 760 - 762
Industry sector: Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 1-4200-6183-6