sample preparation – TechConnect Briefs

Deterministic Lateral Displacement (DLD): Finite element modeling and experimental validation for particle trajectory and separation

Pariset E., Berthier J., Révol-Cavalier F., Pudda C., Gosselin D., Navarro F., Icard B., Agache V., CEA-LETI, FR

In biotechnology and biology, deterministic lateral displacement (DLD) arrays are used to separate particles based on their size, such as cells, bacteria, parasites and exosomes. DLD is very promising for sample preparation purposes as it [...]

Diode Laser Generated Ultrasound for Human Blood Cell Lysis

Ussing T., von Gersdorff L.C., FluimediX, DK

The lysing of human blood leukocyte cells prior to performing e.g. DNA analysis is performed on a routine basis in most biochemical labs. Well-established techniques include using a lysis agent or using mechanical methods such [...]

Biomimetic Design of a Microfluidic Device for Auto-separation of Leukocytes from Whole Blood

Shevkoplyas S.S., Yoshida T., Munn L.L., Bitensky M.W., Boston University, US

Leukocytes comprise less than one percent of all blood cells. Enrichment of their number, starting from a sample of whole blood, is the required first step of many clinical and basic research assays. We created [...]