nanotoxicology – TechConnect Briefs

Nanomaterials in Food and Food Contact Substances – Hazards, Risks and Regulation

Cohen J., Gradient, US

The increasing number and variety of engineered nanomaterials (ENMs) used in food and food contact materials raise concerns regarding potential hazards and risks to human health. ENMs are used for a wide variety of applications [...]

An integrated methodology across the dispersion preparation-characterization-in vitro dosimetry continuum for engineered nanomaterials

Cohen J., DeLoid G., Pirela S., Pyrgiotakis G., Demokritou P., Harvard School of Public Health, US

Evidence continues to grow of the importance of in vitro and in vivo dosimetry in the hazard assessment and ranking of engineered nanomaterials (ENMs). Accurate dose metrics are particularly important for in vitro cellular screening [...]

Evaluation of the genotoxic potential of different types of nanofibrillated celluloses

Catalán J., Lindberg H.K., Aimonen K.J., Wolff H., Wedin I., Nuopponen M., Savolainen K.M., Norppa H., Finnish Institute of Occupational Health, FI

Nanofibrillar cellulose (NFC) is among the most promising innovations in the forest industry. Due to its unique properties, NFC has a wide variety of possible applica-tions. As NFC consists of thin and long fibres with [...]

Co-Culturing Dorsal Root Ganglion Neurons with Schwann Cells Protects Them Against the Cytotoxic Effects of Silver Nanoparticles

Gao W., Leung S.W., Bhushan A., Lai J.C.K., Idaho State University College of Pharmacy, US

Because of their presumed inertness, silver nanoparticles are increasing employed in many consumer products. Nonetheless, their environmental and health hazard impact are not understood. Our previous studies led us to develop a co-culture model consisting [...]

Schwann Cells and Dorsal Root Ganglion Neurons Are Differentially Susceptible to Oxidative Stress Induced by Silicon Dioxide Nanoparticles

Lai J.C.K., Jaiswal A.R., Idikuda V.K., Pfau J., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Silicon dioxide (SiO2) particles, including nanoparticles, have been increasing employed in diverse industrial and biomedical applications including those in drug formulations, food, and cosmetics as SiO2 has been generally regarded as a non-toxic substance. However, [...]

Potential artifacts when evaluating the ecotoxicological effects of nanomaterials

Petersen E.J., Henry T.B., Zhao J., MacCuspie R.I., Kirschling T.L., Xing B., Dobrovolskaia M.A., Hackley V., White J.C., National Institute of Standards and Technology, US

Novel physicochemistries of engineered nanomaterials (ENMs) offer considerable commercial potential for new products and processes, but also the possibility of unforeseen and negative consequences upon ENM release into the environment. Investigations of ENM ecotoxicity have [...]

Potential artifacts when evaluating the ecotoxicological effects of nanomaterials

Petersen E.J., Henry T.B., Zhao J., MacCuspie R.I., Kirschling T.L., Xing B., Dobrovolskaia M.A., Hackley V., White J.C., National Institute of Standards and Technology, US

Novel physicochemistries of engineered nanomaterials (ENMs) offer considerable commercial potential for new products and processes, but also the possibility of unforeseen and negative consequences upon ENM release into the environment. Investigations of ENM ecotoxicity have [...]

Risk Ranking Framework to Assess the Health Hazard of Nanomaterial-Containing Products in an Industrial and Consumer Application Setting

Madl A.K., Unice K., Kreider M., Kovochich M., Bebenek I.G., Abramson M.M., ChemRisk, US

The unique combination of size, structure, morphology, physical/chemical characteristics, and quantum properties of nanomaterials, presents a challenging platform in understanding the potential hazards and health risks of engineered nanomaterials and the products that utilize these [...]

In vivo nanotoxicology: Toxicoproteomics

Sabella S., Kote S., Pompa P.P., Italian Institute of Technology, IT

Proteomics applied to nanotechnology is now emerging as an attractive tool to address the still unanswered questions dealing with nano-biointeractions and NPs-induced toxicity in living systems. The unique advantage provided by “omic” techniques (such as, [...]

Nanomaterials as Nanocomposite Fillers: Cytotoxicity at Different Stages of Their Life Cycle

Mas del Molino E., Vilar G., Janer G., Fernández-Rosas E., Vázquez-Campos S., LEITAT Technological Center, ES

Since the production and utilities of NM have been growing exponentially we have decided to perform cell viability tests and mechanistic assays using different cell lines to assess the potential cytotoxicity of raw MWCNT, hydrophilic [...]