lab-on-a-chip – Page 4 – TechConnect Briefs

Nanofluidic Size Exclusion Chromatograph for In Site Macromolecular analyses

Choi D., Grunthaner F., Feldman S., Svehla D., Jet Propulsion Laboratory/California Institute of Technology, US

We are developing a nanofluidic size exclusion chromatograph (nano-SEC) system that can be incorporated into miniature lab-on-a-chip devices which will provide detailed information on the geochemical and biological history of soil, ice, and water samples [...]

Enhanced Separation Performance in Microfabricated Electrophoresis Devices by Electric Field Induced Collection and Metering of DNA

Shaikh F.A., Ugaz V.M., Texas A&M University, US

Microfluidic technology is a key component in the development of microfabricated lab-on- a-chip systems for use in bioanalytical and biosensing applications. These devices continue to be developed to perform a variety of DNA analysis assays, [...]

Microfluidic Injector Models Based on Neural Networks

Magargle R., Hoburg J.F., Mukherjee T., Carnegie Mellon University, US

An injector modeling methodology based on neural networks is presented. The new aspects of this approach are (1) the full description of the dynamic injector behavior and (2) the applicability of the approach to a [...]

High Sensitivity, Microfluidic Immunoassays utilizing DNA-conjugated Antibodies to Accelerate the Electrophoretic Separation of Antigen-Antibody Complexes

Wada H.G., Kawabata T., Kazakova I., Simeonov A., Park C., Kechagia P., Spaid M., Watanabe M., Satomura S., Wako Pure Chemical Industries Ltd., US

The promise of microfluidic immunoassays in microchips has been the miniaturization, integration and automation of rapid immunoassays. The typical microfluidic assays have used fluorescent dye labeled antibodies in direct binding assays or labeled antigens in [...]

Design Paradigms and Methodologies for Microfluidics

Hardt S., Darmstadt University of Technology, DE

This paper reviews and compares different strategies for designing and building up microfluidic systems, with a special emphasis on the system aspect as opposed to single components capable of performing only special operations. An overwhelming [...]

A Piezoelectric Micro-Cantilever Bio-Sensor Using the Mass-Micro-Balancing Technique with Self-Excitation

Lee Y., Lim G., Moon W., Pohang University of Science and Technology, KR

A new bio-sensor was developed in order to use in a LOC(Lab-On-a-Chip). The sensor detects the change in the resonance frequency of a micro cantilever with a piezoelectric film(PZT). This is the so-called mass micro-balancing [...]

Purification of PCR-Inhibitory Components by Cellulose Acetate Membranes

Mohamed H., Szarowski D.H., Lepak L.A., Spencer M.G., Martin D.L., Caggana M., Turner J.N., New York State Department of Health, US

Conventional methods for extracting DNA from blood results in the presence of heme, which is an inhibitory factor decreasing PCR sensitivity. Current techniques for removing the inhibitors are laborious, costly, and/or sample-specific. We investigated using [...]

Circuit Modeling and Simulation of Integrated Microfluidic Systems

Chatterjee A.N., Aluru N.R., Beckman Institute, US

A combined circuit-device model for the analysis of integrated microfluidic system is presented. The complete model of an integrated microfluidic device incorporates modeling of the fluidic transport, chemical reaction, reagent mixing and separation. The microfluidic [...]

Evaluation of Electric Impedance Spectra for Single Bio-Cells with Microfluidic Devices using Combined FEMLAB/HSPICE Simulated Models

Senez V., Yamamoto T., Poussard B., Fukuba T., Capron J.M., Fujii T., LIMMS/CNRS-IIS - University of Tokyo, JP

This paper describes a simple method to predict the electrical impedance spectrum of single & cultured cells in micro-devices. It can be used for the rapid design of micro-sensors as well as for more fundamental [...]

Microfabricated Fluorescence-Activated Cell Sorter with Hydrodynamic Flow Manipulation

Bang H., Chung C., Chung S., Kim J.K., Kim S., Kim J.K., Kim S., Chung C., Chung S., Han D-C, Chang J.K., School of Mechanical & Aerospace Eng., Seoul National University, KR

Presented is a novel flow manipulation and particle detection method for the microfabricated fluorescence-activated cell sorter (FACS). With hydrodynamic flow manipulation which includes passive flow channeling and hydrodynamic actuation with nozzle flow, we have developed [...]