lab-on-a-chip – TechConnect Briefs

Companion diagnostic test using digital microfluidic

Boizot F., Den Dulk R., Fouillet Y., Fuchs O., Menneteau M., Navarro F., CEA-LETI, FR

Companion diagnostics are an indispensable part of personalized medicine, providing information that is essential for the safe and effective use of a corresponding therapeutic drug. Such devices need to be robust, transportable and easy to [...]

A stand-alone and portable microfluidic platform for quantitative multi-step assays

Boizot F., Charles R., Fouillet Y., L. Achard J-, Parent C., Verplanck N., CEA-LETI, FR

This paper reports an automated platform for quantitative multi-step assays composed of two main components: a microfluidic chip using collapsible chambers pneumatically actuated and a portable instrument to automate the fluidic operations. To achieve a [...]

A compact syringe-assisted vacuum-driven micropumping with a constant flow rate

Koh D., Oh K.W., Schneider P., Wang A., University at Buffalo, US

Abstract In this paper, a simple syringe-assisted pumping method was introduced. Compared with previous study [1], the proposed design does not require pre-designed vacuum chambers, the multiple pumps can be integrated into one device and [...]

A simple process for selective bio-functionalization of SU-8 surface for Lab-on-a-Chip applications

Chaurasia D., Singh S., Srinivasan B., Vanjari S., Indian Institute of Technology - Hyderabad, IN

SU-8 is a popular epoxy based negative photoresist developed by IBM. It has been widely used as structural material in Bio-MEMS and Lab-on-a-Chip devices due to its bio-compatible properties. SU-8 surface has hydrophobic nature. Often [...]

A CMOS Lab-On-A-Chip For Neuron Monitoring And Stimulation

Ghallab Y.H., Ismail Y., Center of Nano Electronics and Devices (CND) at American University in Cairo/ Zewail City of Science and Technology, Cairo, Egypt, EG

Many tools have been established to monitor neural activity such as patch pipettes and microelectrodes, which are electrolyte filled glass tubes used to create intracellular contacts by rupturing the cell membrane and directly measuring the [...]

Metrology for Lab on a Chip Final Product Devices

Halter M., Hwanga J., Reyes D.R., National Institute of Standards and Technology, US

New metrology tools to measure the critical parameters of internal structures in lab on a chip devices are greatly needed in order to develop standard tests for this technology. Here we present a method that [...]

An Integrated Microfluidic Real-Time PCR System for Pathogen Detection

An D., Li L., Li Z., Lin F., Liu Y., Wang M., Wang Y.K., Zhang G., Zhang L., Zhu L., University of Manitoba, CA

The development of microfluidics-based PCR for rapid genetic analysis particularly pathogen detection is an emerging research field. Recent advancement of microfluidics critically enabled the development of various on-chip PCR systems to realize its apparent advantages [...]

Functional Performance of Microfluidic On-Board Pumps and Valves with Various Actuation Protocols

Levine L., McDowell J., Podczeviensky J., ALine, Inc., US

Microfluidics are critical to the development of high sensitivity, multiplexed, and quantitative point-of-care diagnostic products that promise to improve the quality of healthcare while lowering costs. Fundamental to a shift from qualitative screening tests to [...]

A Novel Compact Lab-on-a-Chip Nanosensor for In-Channel Liquid Viscosity Detection

Xu J., Xue W., Zhao J., Washington State University Vancouver, US

Real-time monitoring of liquid’s viscosity has significant impacts on many areas such as medicine, biology and petrochemistry. However, most existing sensors have complicated fabrication and testing processes and are not truly compatible with fluidic systems [...]

Polymer microfluidic chip with embedded CNTs for DNA sample preparation

Chan J.X., Gong M., Khuntontong P., Wang Z.P., Singapore Institute of Manufacturing Technology, SG

We present a polymer-based microfluidic chip which has deposited carbon nanotubes (CNTs) onto the microchannel. The chip is capable of performing DNA preparation process like restriction enzyme digestion and ligation of DNA. The advantage of [...]