hyperthermia – Page 2 – TechConnect Briefs

Multi- Walled Carbon Nanotubes Increase the Efficiency of Hyperthermic Chemotherapy

Levi-Polyachenko N.H., Merkel E., Jones B.T., Wagner W.D., Carroll D.L., Stewart IV J.H., Wake Forest University Health Sciences, US

A clinically applied method to enhance drug localization for abdominal malignancies of colorectal cancer involves a two-hour perfusion of hyperthermic (40-42ºC) chemotherapeutic agents; however, all cavity tissues are subjected to enhanced drug delivery due to [...]

Preparation and investigation of biological activity of thermosensitive liposomes loaded with doxorubicin

Tazina E.V., Polozkova A.V., Orlova O.L., Ignatieva E.V., Mescherikova V.V., Wainson A., Yarmonenko S.P., Oborotova N.A., N.N.Blokhin Russian Cancer Research Center of RAMS, RU

Purpose: Preparation of thermoliposomes with doxorubicin and investigation of their effect on solid Ehrlich carcinoma and B-16 mouse melanoma in combination with hyperthermia. Materials and methods: Thermosensitive liposomes were prepared using DPPC, DSPC, DSPE-PEG 2000 [...]

In vitro & in vivo toxicity of CoFe2O4 nanoparticles for application to magnetic hyperthermia

Kim D-H., Kim K-M, Kim K.N., Kim D-H., Kim K-M, Kim K.N., Kim D-H., Kim K-M, Kim K.N., Shim I-B, Lee Y.K., The University of Alabama, Tuscaloosa, US

Magnetic nanoparticles offer some attractive possibilities in biomedicine because it has the special physical properties. So, we can usually consider four particular applications: magnetic separation, drug delivery, hyperthermia treatments and magnetic resonance imaging (MRI) contrast [...]

Hyperhtermia effect of surface-modified magnetite nanoparticles in a microfluid system

Lin C.Y., Ho K.C., National Taiwan University, TW

Fe3O4 nanoparticles (NPs) was first synthesized via coprecipiatation. After synthesis and purification of the Fe3O4 NPs, poly(acrylic acid) (PAA) was coated on them at specified conditions. The coating process is not possible at pH higher [...]

Synthesis of superparamagnetic magnetite nanoparticles for thermoresponsive drug delivery

Lin C.Y., Ho K.C., National Taiwan University, TW

Superparamagnetic magnetite nanoparticles (MNPs) were synthesized via modified coprecipitation method and their physical properties were examined. The crystal structure of Fe3O4 nanoparticles (NPs) was confirmed by X-ray diffraction. From the dynamic laser scattering analysis, the [...]

Shape-controlled synthesis and functionalization of gold nanoparticles for hyperthermia applications

Van de Broek B., Frederix F., Bonroy K., Jans H., Maes G., Borghs G., IMEC, BE

Control of nanoparticle shape may initially seem like a scientific curiosity, but its goal goes far beyond aesthetic appeal. The shape not only influences the chemical and optical properties of metal nanoparticles, but also their [...]

Targeting Nanoparticles to Tumors using Adenoviral Vectors

Saini V., Enervold M.R., Perez A., Koploy A., Perkins G., Ellisman M.H., Green H.N., Mirov S.B., Zharov V.P., Everts M., University of Alabama at Birmingham, US

Despite advances in detection and treatment of cancer, development of novel therapies remains essential; in this regard, nanotechnology holds great promise. For example, tumor imaging opportunities have expanded by the development of quantum dots (QDs) [...]

Magnetic Nanoparticles for Self Controlled Hyperthermia Treatment of Tumors

Haik Y., Mohite V., Chen C-J., Center for Nanomagnetics and Biotechnology, US

Self controlled magnetic hyperthermia at tumor sites requires magnetic particles with Curie temperature similar to that of the desired tumor temperature. Elevated temperature at the tumor site was reported to decrease the tumor resistivety to [...]

Bioactive Ferrimagnetic Glass-Ceramics for Magnetic Induction Hyperthermia

Bretcanu O., Vernè E., University "Politecnico di Torino", IT

Ferrimagnetic glass-ceramics are potential candidates for magnetic induction hyperthermia, which is one form of inducing deep-regional hyperthermia, by using a magnetic field. The aim of this work is the preparation and characterization of innovative bioactive [...]