drug delivery – Page 7 – TechConnect Briefs

Multiscale Approach to Nanocapsule Design

Shreif Z., Ortoleva P., Indiana University, US

A methodology for the computer-aided design of nanocapsules for the targeted delivery of therapeutic agents is presented. Previous models are macroscopic and, therefore, do not take into consideration atomistic effects and, furthermore, require recalibration with [...]

Carbon Nanopipes dispersions in aqueous solutions and effects on cell viability

Whitby M., Lin J., Quirke N., Thanou M., Imperial College London, UK

The development of carbon nanomaterials for biomedical applications appears highly attractive due to their nanoscale properties although their biological profile is still in doubt. Herewith, we report that the amorphous vs crystalline character of carbon [...]

Landscape Phage Probes for Breast Cancer Cells

Fagbohun O.A., Bedi D., Jayanna P.K., Deinnocentes P.A., Bird R.C., Petrenko V.A., Auburn University, US

Landscape phage libraries are collections of filamentous phages displaying random foreign peptides on all 4,000 surface domains of the major coat protein. They serve as a rich source of bioselective materials that are used in [...]

Landscape phage probes for PC3 prostate carcinoma cells

Jayanna P.K., Deinnocentes P., Bird R.C., Petrenko V.A., Auburn University, US

Cancer chemotherapy is complicated by a lack of selective drug targets. The use of liposomes as vectors for drug delivery has provided a route to selective accumulation of nanoparticles in the tumor interstitium due to [...]

DNA-Associated Single-walled Carbon Nanotubes as a Platform for Drug Delivery

Dolash B.D., Lahiji R.R., Zemlyanov D.Y., Reifenberger R., Bergstrom D.E., Purdue University, US

DNA-associated single walled carbon nanotubes(DNA:SWCNTs) have shown potential in drug delivery with the ability to translocate across the cell membrane carrying various biomolecules. Our laboratory has completed a series of experiments to show the sonication [...]

Multi- Walled Carbon Nanotubes Increase the Efficiency of Hyperthermic Chemotherapy

Levi-Polyachenko N.H., Merkel E., Jones B.T., Wagner W.D., Carroll D.L., Stewart IV J.H., Wake Forest University Health Sciences, US

A clinically applied method to enhance drug localization for abdominal malignancies of colorectal cancer involves a two-hour perfusion of hyperthermic (40-42ºC) chemotherapeutic agents; however, all cavity tissues are subjected to enhanced drug delivery due to [...]

Production of Polymer Nanosuspensions Using MicrofluidizerTM Processor Based Processes

Panagiotou T., Mesite S.V., Bernard J.M., Chomistek K.J., Fisher R.J., Microfluidics, US

Two techniques are reported here that can create nano-suspensions of many different polymers types with varying particle sizes by controlling the formulation and process variables. Microfluidics Reaction Technology (MRT) was used with the solvent anti/solvent [...]

Novel piezo motor enables positive displacement microfluidic pump

Henderson D., New Scale Technologies, US

Microfluidic pumping mechanisms, such as membrane micro pumps, create a pulsed stream with generally low pressure, low flow and limited precision. We present a novel piezoelectric motor that is used to create a positive displacement [...]

Phage-Derived Bioselective Nanovehicles for Drug and Gene Delivery

Petrenko V.A., Auburn University, US

Phage display technology rests on two fundamental concepts: combinatorial chemistry and fusion phage. We first demonstrated fusion of the major coat protein of the phage with foreign random peptides, which results in landscape phage libraries. [...]

Synthesis of superparamagnetic magnetite nanoparticles for thermoresponsive drug delivery

Lin C.Y., Ho K.C., National Taiwan University, TW

Superparamagnetic magnetite nanoparticles (MNPs) were synthesized via modified coprecipitation method and their physical properties were examined. The crystal structure of Fe3O4 nanoparticles (NPs) was confirmed by X-ray diffraction. From the dynamic laser scattering analysis, the [...]