drug delivery – Page 8 – TechConnect Briefs

The Effect of Water on Particle Size, porosity, and the Rate of Drug Release from Implanted Titania Resrvoirsia

Lopez T., Hernandez-Ayala A., Odriozola J.A., Quintana P., Gonzalez R.D., Lottici P.P., Marino I., Tulane University, US

In this study, sol-gel titania implants used in the controlled rate of drug release of valproic acid to the temporal lobe of the brain were optimized to insure that the correct drug dose is delivered. [...]

Spectroscopical and Structural Studies of Sol-gel Reservoirs used as Implants in the Delivery of Dopamine to the Central Nervous System

Lopez T., Esquivel D., Ascencio J., Odriozola J.A., Gonzalez R.D., Tulane University, US

The stabilization of dopamine used in the treatment of Parkinsons is a pressing problem. When dopamine is applied systemically. destabilization may occur following penetration through the blood brain barrier (BBB). In order to circumvent this [...]

Specific targeting and delivery of virus envelope-coated nanoparticle cargoes into receptor-bearing cells and subcellular compartments

Moore A.C., Kolokoltsov A.A., Davey R.A., University of Texas Medical Branch, US

We build on our recently reported work in Nano letters describing coating of nanoparticle cargoes with virus envelope proteins to show that the method works for viruses other than ecotropic murine leukemia viruses. We also [...]

Mathematical model of drug delivery using Anti-cancerous Herbal drugs

Katiyar V.K., Pathak P., Indian Institute of Technology, Roorkee, IN

Pharmacokinetics deals with the distribution of drugs, chemicals, tracers or radioactive substance among the various compartments of the human body. Compartment modeling is very convenient for biochemical transformation. In this paper, we have used basic [...]

Scalable Fabrication of Polymeric and Organic Nanomaterials using Particle Replication in Non-wetting Templates (PRINT) and Imprint Lithography

Maynor B.W., Denison G.M., Rolland J.P., DeSimone J.M., Liquidia Technologies, US

We have developed scalable, “top-down” nanofabrication methodologies for the fabrication of polymeric and organic nanostructures for nanobiotechnology and materials engineering. These techniques use novel perfluoropolyether (PFPE) elastomers that possess superior nanoimprinting properties, including error-free nanoscale [...]

Full Coupling Simulation of a Membrane Micropump

Yao Q., Xu D., Pan L.S., Melissa Teo A.L., Ho W.M., Peter Lee V.S., Shabbir M., Institute of High Performance Computing, SG

The design of PZT actuated valveless membrane micropumps is a very complex process as it involves the knowledge of electro mechanics, solid mechanics and fluid mechanics. So far, there is no accurate, flexible and broadly [...]

Chitosan Nanoparticles for the Effective Vaccine Delivery System

Kim B.G., Kang I.J., Kyungwon University, KR

There are four genes of S, C, X, P in HV DNA. S gene has the pre-S region composed of pre-S1 and pre-S2 as an encoding gene of surface antigen. C gene is in the [...]

Nanotechnology for Drug Delivery: An Overview

Amiji M.M., Northeastern University, US

Nanotechnology is expected to have a revolutionary impact on biology and medicine. In this paper, I will discuss the role of nanotechnology in development of site-specific drug delivery systems. Polymeric nanoparticles, lipid nanosystems, and self-assembling [...]

Novel Photonic Technique Creates Micrometer Resolution Multi-sensor Arrays and Provides a New Approach to Coupling of Genes, Nucleic Acids, Peptide Hormones and Drugs to Nanoparticle Carriers

Neves-Petersen M.T., Duroux L., Duroux M., Duroux L., Duroux M., Skovsen E., Neves-Petersen M.T., Petersen S.B., Professor, DK

Photonic induced immobilisation is a novel patented technology resulting in spatially oriented and localised covalent coupling of biomolecules onto surfaces. Immobilisation has been achieved for a wide selection of proteins, e.g., human plasminogen, alkaline phosphatase, [...]

Nano-structured Biodegradable Ceramics for the Prevention and Treatment of Bone Caner

Balasundaram G., Webster T.J., Purdue University, US

For people dying of some cancers such as breast and prostate, the spread of bone cancer is almost universal. Although current drug delivery systems have found a variety of uses in targeting certain forms of [...]