Bionanobots for drug delivery
This paper describes simulations of dendrimers of generation 4, for the transport of drugs to combat tuberculosis. One of the main causes of death in patients who have HIV. We used molecular modeling of large [...]
Keywords: drug delivery
Generation of monodisperse microemulsions in the colloidal range and stabilized monodisperse microbubbles with diameters of $5$ microns using two different types of micro fluidic devices
Gordillo J.M., Castro-Hernandez E., van Hoeve W., Campo-Cortes F., Lohse D., Universidad de Sevilla, ES
Here we propose two different ways to generate either monodisperse microemulsions or monodisperse microbubbles. With the first of these techniques a jet is formed with the same type of cone-jet geometry predicted by the numerical [...]
Lipid nanoparticles: tumor-targeting nanocargos for drug and contrast agent delivery
Delmas T., Navarro F., Gravier J., Thomann J.S., Heinrich E., Mérian J., Fraichard A., Boisgard R., Tavitian B., Dufort S., Coll J.L., Bibette J., Boisseau P., Couffin A.C., Texier I., CEA-Grenoble, FR
A new technology for the encapsulation of lipophilic molecules -both drugs and contrast agents dedicated to chemotherapy, phototherapy, or fluorescence imaging in oncology- has been developed, based on oil-in-water nanoemulsions. Thorough physico-chemical characterizations of the [...]
Polymersome macromolecule delivery across intact human skin
Skin is a highly stratified and impermeable tissue that confers specific size, charge, hydrophilic and lipophilic constraints on the types of molecules that can diffuse across it. Here we report the use of a novel [...]
Label-free Raman Micro-Spectral Imaging of the Microenvironment of PANC-1 Spheroids
Spheroids are 3D tumor models, which reflect diverse properties of the growing tumor. Due to its avascular microenvironment, initial tumor growth patterns as well as subsequent tumor-core biochemistry may be studied in depth, from which [...]
Nanoencapsulated Drug-Carrying System for Photodynamic Antimicrobial Chemotherapy (PACT)
Chronic wounds are considered as a pandemic health problem. Approximately 1% to 2% of the population in developing countries has experienced a chronic wound during their lifetime. In the United State States,the expense of treating [...]
A Non-toxic Cellular Staining Agent Based on Fluorescently Labeled Poly[2-(methacryloyloxy)ethyl phosphorylcholine]
The biocompatible monomer 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) is polymerized by atom transfer radical polymerization (ATRP) using a fluorescent ATRP initiator and fluorescent comonomers. In this study we show that PMPC alone can be used as a [...]
Synthesis and Characterization of Superparamagnetic Nanoparticles Coated with Carboxymethylated Cassava Starch for Drug Delivery System
Kasemwong K., Nanta P., Skolpap W., Ruktanonchai U.R., Nano Delivery System Laboratory, National Nanotechnology Center, TH
Magnetic nanoparticles (MNPs) are increasingly being considered for a number of biomedical applications due to their inherent ultra fine size, biocompatibility and superparamagnetic properties. The functional properties of the MNPs can be tailored for specific [...]
beta-casein micelles and nanocapsules in drug delivery
β-casein, the main protein found in milk, is an amphiphilic molecule that forms micelles both above and below the pI. In the presented work we investigated the possible use of β-casein micelles as a vehicle [...]
Spectrally-Selective Light-Induced Release from Gold-Coated Liposomes
To address unmet medical needs in the area of controlled delivery, we recently presented liposome-supported plasmon resonant gold nanoshells. These composite structures are degradable into components of a size compatible with renal clearance, potentially enabling [...]