drug delivery – TechConnect Briefs

Liquid core nanocapsules synthesized using flash nanoprecipitation

Van Keuren E., Taylor S., Chung Y., Chen L., Ugwu-Uche U., Aparicio V.A., Meehan R., Hughes E., Georgetown University, US

The synthesis and application of multicomponent and/or multifunctional nanoparticles is an area that has seen significant growth over the past decade. Nanocapsules, nanoparticles with a liquid core and hard shell, are one example. They have [...]

Hybrid Programmable Peptide Crosslinkers as Enzyme-Regulated Drug Delivery Vehicles

Rouge J.L., University of Connecticut, US

Biology has evolved the quintessential nucleic acid delivery vehicle, the virus, using proteins built from self-assembled peptide subunits. These viral protein coats are then degraded by specific enzymes, depending on their location, releasing their contents [...]

Zwitterionic Polymer Surfactants for Drug Delivery

Cao Z., Wayne State University, US

Zwitterionic polymers have found a wide range of applications based on excellent non-fouling properties. It has been demonstrated that their use as surface coatings can effectively resist binding from proteins, cells, and full blood. Nanoparticles [...]

Functional Polylactide-based Systems for Delivery of Cancer Therapeutics

Cheng C., Sun H., Yu Y., Chen C-K, Cheng C., Zou J., University at Buffalo, the State University of New York, US

As an important class of biodegradable polymers, polylactides (PLAs) have been approved by FDA for clinical applications. However, conventional PLAs are lack of functionalities, and this significantly limits their applications. Therefore, in recent years we [...]

Modeling of polypeptide- and polymer-conjugated nanoparticles for drug delivery application

Lee H.K., Dankook University, KR

Nanoparticles such as liposomes, dendrimers, and carbon nanotubes have many potential biomedical applications as antitumor therapeutics and drug delivery. These applications require the interaction of those with cell membranes, thus interactions of nanoparticles, polymers, and [...]

Visible Light Absorbing Photoremovable Protecting Groups

Juetten M., Iowa State University Research Foundation, US

Photoremovable protecting groups (or “photocages” or “phototriggers”) are light-sensitive chemical moieties that provide control over the release of any number of reagents in a variety of environments. While photocages have important applications in areas such [...]

Enhancement of anticancer action of traditional (doxorubicin and cisplatin) and experimental (landomycin A) drugs by their delivery in vivo with novel C60-fullerene-based nanocarriers possessing innate ROS-modulating activity

Panchuk R., Prylutska S., Skorokhyd N., Lehka L., Skivka L., Hurmach V., Evstigneev M., Piosik J., Berger W., Prylutskyy Yu., Scharff P., Stoika R., Vari S., Institute of Cell Biology NAS of Ukraine, UA

Rapid development of multi-drug resistance of tumor cells to chemotherapy caused by the over-expression of specific ABC-transporter proteins and/or multiple defects in genes involved in cell cycle and apoptosis regulation in cancer cells frequently leads [...]

DEVELOPMENT OF SUSTAIN RELEASE POVIDONE IODINE OPHTHALMIC DROP THROUGH NOVEL IN-SITU GEL FORMULATION

Wei G., Gao X., Li X., Liang B., Lu Y., Baldwin J.J., Liang B., IVIEW Therapeutics Inc., US

Acute conjunctivitis (“pink eye”) is one of the most common and most contagious ocular infections seen in the United States, Japan and Europe. There are 5.9 million cases of infectious conjunctivitis annually in the United [...]

Bilayer coated ureteral stent as drug delivery platform to treat ureteric diseases

Lim W., Xiong G.M., Chong T.W., Huang Y., Venkatraman S., Nanyang Technological University, SG

The current methods of treating ureteric diseases such as strictures and carcinoma include endoscopic full-thickness incision of the ureteric wall and placement of an indwelling stent for up to 6 weeks. However, such interventions are [...]

Conjugation of anticancer drugs with novel PEG-containing nanocarrier provides circumvention of drug-resistance mechanisms in vitro and protects of general toxicity in vivo

Kоbylinska L., Panchuk R., Skorohyd N., Senkiv Y., Heffeter P., Berger W., Boiko N., Mitina N., Zaichenko A., Lesyk R., Zіmenkovsky B., Stoika R., Vari G.S., Danylo Halytsky Lviv National Medical University, UA

In the last decade, the development of targeted drug delivery with conjugated nanoparticles brings more drug molecules to the diseased sites, at the same time reducing a systemic drug exposure. Polyethylene glycol (PEG) conjugation is [...]